Role for the Unfolded Protein Response in Heart Disease and Cardiac Arrhythmias

The unfolded protein response (UPR) has been extensively investigated in neurological diseases and diabetes, while its function in heart disease is less well understood. Activated UPR participates in multiple cardiac conditions and can either protect or impair heart function. Recently, the UPR has b...

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Detalles Bibliográficos
Autores principales: Liu, Man, Dudley, Samuel C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730297/
https://www.ncbi.nlm.nih.gov/pubmed/26729106
http://dx.doi.org/10.3390/ijms17010052
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author Liu, Man
Dudley, Samuel C.
author_facet Liu, Man
Dudley, Samuel C.
author_sort Liu, Man
collection PubMed
description The unfolded protein response (UPR) has been extensively investigated in neurological diseases and diabetes, while its function in heart disease is less well understood. Activated UPR participates in multiple cardiac conditions and can either protect or impair heart function. Recently, the UPR has been found to play a role in arrhythmogenesis during human heart failure by affecting cardiac ion channels expression, and blocking UPR has an antiarrhythmic effect. This review will discuss the rationale for and challenges to targeting UPR in heart disease for treatment of arrhythmias.
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spelling pubmed-47302972016-02-11 Role for the Unfolded Protein Response in Heart Disease and Cardiac Arrhythmias Liu, Man Dudley, Samuel C. Int J Mol Sci Review The unfolded protein response (UPR) has been extensively investigated in neurological diseases and diabetes, while its function in heart disease is less well understood. Activated UPR participates in multiple cardiac conditions and can either protect or impair heart function. Recently, the UPR has been found to play a role in arrhythmogenesis during human heart failure by affecting cardiac ion channels expression, and blocking UPR has an antiarrhythmic effect. This review will discuss the rationale for and challenges to targeting UPR in heart disease for treatment of arrhythmias. MDPI 2015-12-31 /pmc/articles/PMC4730297/ /pubmed/26729106 http://dx.doi.org/10.3390/ijms17010052 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Liu, Man
Dudley, Samuel C.
Role for the Unfolded Protein Response in Heart Disease and Cardiac Arrhythmias
title Role for the Unfolded Protein Response in Heart Disease and Cardiac Arrhythmias
title_full Role for the Unfolded Protein Response in Heart Disease and Cardiac Arrhythmias
title_fullStr Role for the Unfolded Protein Response in Heart Disease and Cardiac Arrhythmias
title_full_unstemmed Role for the Unfolded Protein Response in Heart Disease and Cardiac Arrhythmias
title_short Role for the Unfolded Protein Response in Heart Disease and Cardiac Arrhythmias
title_sort role for the unfolded protein response in heart disease and cardiac arrhythmias
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730297/
https://www.ncbi.nlm.nih.gov/pubmed/26729106
http://dx.doi.org/10.3390/ijms17010052
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