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New 9-Hydroxybriarane Diterpenoids from a Gorgonian Coral Briareum sp. (Briareidae)
Six new 9-hydroxybriarane diterpenoids, briarenolides ZI–ZVI (1–6), were isolated from a gorgonian coral Briareum sp. The structures of briaranes 1–6 were elucidated by spectroscopic methods and by comparison of their spectroscopic data with those of related analogues. Briarenolides ZII (2) and ZVI...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730323/ https://www.ncbi.nlm.nih.gov/pubmed/26761004 http://dx.doi.org/10.3390/ijms17010079 |
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| author | Su, Yin-Di Sung, Chun-Sung Wen, Zhi-Hong Chen, Yu-Hsin Chang, Yu-Chia Chen, Jih-Jung Fang, Lee-Shing Wu, Yang-Chang Sheu, Jyh-Horng Sung, Ping-Jyun |
| author_facet | Su, Yin-Di Sung, Chun-Sung Wen, Zhi-Hong Chen, Yu-Hsin Chang, Yu-Chia Chen, Jih-Jung Fang, Lee-Shing Wu, Yang-Chang Sheu, Jyh-Horng Sung, Ping-Jyun |
| author_sort | Su, Yin-Di |
| collection | PubMed |
| description | Six new 9-hydroxybriarane diterpenoids, briarenolides ZI–ZVI (1–6), were isolated from a gorgonian coral Briareum sp. The structures of briaranes 1–6 were elucidated by spectroscopic methods and by comparison of their spectroscopic data with those of related analogues. Briarenolides ZII (2) and ZVI (6) were found to significantly inhibit the expression of the pro-inflammatory inducible nitric oxide synthase (iNOS) protein of lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. |
| format | Online Article Text |
| id | pubmed-4730323 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2016 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-47303232016-02-11 New 9-Hydroxybriarane Diterpenoids from a Gorgonian Coral Briareum sp. (Briareidae) Su, Yin-Di Sung, Chun-Sung Wen, Zhi-Hong Chen, Yu-Hsin Chang, Yu-Chia Chen, Jih-Jung Fang, Lee-Shing Wu, Yang-Chang Sheu, Jyh-Horng Sung, Ping-Jyun Int J Mol Sci Article Six new 9-hydroxybriarane diterpenoids, briarenolides ZI–ZVI (1–6), were isolated from a gorgonian coral Briareum sp. The structures of briaranes 1–6 were elucidated by spectroscopic methods and by comparison of their spectroscopic data with those of related analogues. Briarenolides ZII (2) and ZVI (6) were found to significantly inhibit the expression of the pro-inflammatory inducible nitric oxide synthase (iNOS) protein of lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. MDPI 2016-01-09 /pmc/articles/PMC4730323/ /pubmed/26761004 http://dx.doi.org/10.3390/ijms17010079 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Article Su, Yin-Di Sung, Chun-Sung Wen, Zhi-Hong Chen, Yu-Hsin Chang, Yu-Chia Chen, Jih-Jung Fang, Lee-Shing Wu, Yang-Chang Sheu, Jyh-Horng Sung, Ping-Jyun New 9-Hydroxybriarane Diterpenoids from a Gorgonian Coral Briareum sp. (Briareidae) |
| title | New 9-Hydroxybriarane Diterpenoids from a Gorgonian Coral Briareum sp. (Briareidae) |
| title_full | New 9-Hydroxybriarane Diterpenoids from a Gorgonian Coral Briareum sp. (Briareidae) |
| title_fullStr | New 9-Hydroxybriarane Diterpenoids from a Gorgonian Coral Briareum sp. (Briareidae) |
| title_full_unstemmed | New 9-Hydroxybriarane Diterpenoids from a Gorgonian Coral Briareum sp. (Briareidae) |
| title_short | New 9-Hydroxybriarane Diterpenoids from a Gorgonian Coral Briareum sp. (Briareidae) |
| title_sort | new 9-hydroxybriarane diterpenoids from a gorgonian coral briareum sp. (briareidae) |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730323/ https://www.ncbi.nlm.nih.gov/pubmed/26761004 http://dx.doi.org/10.3390/ijms17010079 |
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