Cargando…
miRNAs Regulation and Its Role as Biomarkers in Endometriosis
MicroRNAs (miRNAs) are small non-coding RNAs (18–22 nt) that function as modulators of gene expression. Since their discovery in 1993 in C. elegans, our knowledge about their biogenesis, function, and mechanism of action has increased enormously, especially in recent years, with the development of d...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730335/ https://www.ncbi.nlm.nih.gov/pubmed/26771608 http://dx.doi.org/10.3390/ijms17010093 |
_version_ | 1782412379004338176 |
---|---|
author | Marí-Alexandre, Josep Sánchez-Izquierdo, Dolors Gilabert-Estellés, Juan Barceló-Molina, Moisés Braza-Boïls, Aitana Sandoval, Juan |
author_facet | Marí-Alexandre, Josep Sánchez-Izquierdo, Dolors Gilabert-Estellés, Juan Barceló-Molina, Moisés Braza-Boïls, Aitana Sandoval, Juan |
author_sort | Marí-Alexandre, Josep |
collection | PubMed |
description | MicroRNAs (miRNAs) are small non-coding RNAs (18–22 nt) that function as modulators of gene expression. Since their discovery in 1993 in C. elegans, our knowledge about their biogenesis, function, and mechanism of action has increased enormously, especially in recent years, with the development of deep-sequencing technologies. New biogenesis pathways and sources of miRNAs are changing our concept about these molecules. The study of the miRNA contribution to pathological states is a field of great interest in research. Different groups have reported the implication of miRNAs in pathologies such as cancer, diabetes, cardiovascular, and gynecological diseases. It is also well-known that miRNAs are present in biofluids (plasma, serum, urine, semen, and menstrual blood) and have been proposed as ideal candidates as disease biomarkers. The goal of this review is to highlight the current knowledge in the field of miRNAs with a special emphasis to their role in endometriosis and the newest investigations addressing the use of miRNAs as biomarkers for this gynecological disease. |
format | Online Article Text |
id | pubmed-4730335 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-47303352016-02-11 miRNAs Regulation and Its Role as Biomarkers in Endometriosis Marí-Alexandre, Josep Sánchez-Izquierdo, Dolors Gilabert-Estellés, Juan Barceló-Molina, Moisés Braza-Boïls, Aitana Sandoval, Juan Int J Mol Sci Review MicroRNAs (miRNAs) are small non-coding RNAs (18–22 nt) that function as modulators of gene expression. Since their discovery in 1993 in C. elegans, our knowledge about their biogenesis, function, and mechanism of action has increased enormously, especially in recent years, with the development of deep-sequencing technologies. New biogenesis pathways and sources of miRNAs are changing our concept about these molecules. The study of the miRNA contribution to pathological states is a field of great interest in research. Different groups have reported the implication of miRNAs in pathologies such as cancer, diabetes, cardiovascular, and gynecological diseases. It is also well-known that miRNAs are present in biofluids (plasma, serum, urine, semen, and menstrual blood) and have been proposed as ideal candidates as disease biomarkers. The goal of this review is to highlight the current knowledge in the field of miRNAs with a special emphasis to their role in endometriosis and the newest investigations addressing the use of miRNAs as biomarkers for this gynecological disease. MDPI 2016-01-13 /pmc/articles/PMC4730335/ /pubmed/26771608 http://dx.doi.org/10.3390/ijms17010093 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Marí-Alexandre, Josep Sánchez-Izquierdo, Dolors Gilabert-Estellés, Juan Barceló-Molina, Moisés Braza-Boïls, Aitana Sandoval, Juan miRNAs Regulation and Its Role as Biomarkers in Endometriosis |
title | miRNAs Regulation and Its Role as Biomarkers in Endometriosis |
title_full | miRNAs Regulation and Its Role as Biomarkers in Endometriosis |
title_fullStr | miRNAs Regulation and Its Role as Biomarkers in Endometriosis |
title_full_unstemmed | miRNAs Regulation and Its Role as Biomarkers in Endometriosis |
title_short | miRNAs Regulation and Its Role as Biomarkers in Endometriosis |
title_sort | mirnas regulation and its role as biomarkers in endometriosis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730335/ https://www.ncbi.nlm.nih.gov/pubmed/26771608 http://dx.doi.org/10.3390/ijms17010093 |
work_keys_str_mv | AT marialexandrejosep mirnasregulationanditsroleasbiomarkersinendometriosis AT sanchezizquierdodolors mirnasregulationanditsroleasbiomarkersinendometriosis AT gilabertestellesjuan mirnasregulationanditsroleasbiomarkersinendometriosis AT barcelomolinamoises mirnasregulationanditsroleasbiomarkersinendometriosis AT brazaboilsaitana mirnasregulationanditsroleasbiomarkersinendometriosis AT sandovaljuan mirnasregulationanditsroleasbiomarkersinendometriosis |