Retinal Cell Degeneration in Animal Models

The aim of this review is to provide an overview of various retinal cell degeneration models in animal induced by chemicals (N-methyl-d-aspartate- and CoCl(2)-induced), autoimmune (experimental autoimmune encephalomyelitis), mechanical stress (optic nerve crush-induced, light-induced) and ischemia (...

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Autores principales: Niwa, Masayuki, Aoki, Hitomi, Hirata, Akihiro, Tomita, Hiroyuki, Green, Paul G., Hara, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730351/
https://www.ncbi.nlm.nih.gov/pubmed/26784179
http://dx.doi.org/10.3390/ijms17010110
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author Niwa, Masayuki
Aoki, Hitomi
Hirata, Akihiro
Tomita, Hiroyuki
Green, Paul G.
Hara, Akira
author_facet Niwa, Masayuki
Aoki, Hitomi
Hirata, Akihiro
Tomita, Hiroyuki
Green, Paul G.
Hara, Akira
author_sort Niwa, Masayuki
collection PubMed
description The aim of this review is to provide an overview of various retinal cell degeneration models in animal induced by chemicals (N-methyl-d-aspartate- and CoCl(2)-induced), autoimmune (experimental autoimmune encephalomyelitis), mechanical stress (optic nerve crush-induced, light-induced) and ischemia (transient retinal ischemia-induced). The target regions, pathology and proposed mechanism of each model are described in a comparative fashion. Animal models of retinal cell degeneration provide insight into the underlying mechanisms of the disease, and will facilitate the development of novel effective therapeutic drugs to treat retinal cell damage.
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spelling pubmed-47303512016-02-11 Retinal Cell Degeneration in Animal Models Niwa, Masayuki Aoki, Hitomi Hirata, Akihiro Tomita, Hiroyuki Green, Paul G. Hara, Akira Int J Mol Sci Review The aim of this review is to provide an overview of various retinal cell degeneration models in animal induced by chemicals (N-methyl-d-aspartate- and CoCl(2)-induced), autoimmune (experimental autoimmune encephalomyelitis), mechanical stress (optic nerve crush-induced, light-induced) and ischemia (transient retinal ischemia-induced). The target regions, pathology and proposed mechanism of each model are described in a comparative fashion. Animal models of retinal cell degeneration provide insight into the underlying mechanisms of the disease, and will facilitate the development of novel effective therapeutic drugs to treat retinal cell damage. MDPI 2016-01-15 /pmc/articles/PMC4730351/ /pubmed/26784179 http://dx.doi.org/10.3390/ijms17010110 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Niwa, Masayuki
Aoki, Hitomi
Hirata, Akihiro
Tomita, Hiroyuki
Green, Paul G.
Hara, Akira
Retinal Cell Degeneration in Animal Models
title Retinal Cell Degeneration in Animal Models
title_full Retinal Cell Degeneration in Animal Models
title_fullStr Retinal Cell Degeneration in Animal Models
title_full_unstemmed Retinal Cell Degeneration in Animal Models
title_short Retinal Cell Degeneration in Animal Models
title_sort retinal cell degeneration in animal models
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730351/
https://www.ncbi.nlm.nih.gov/pubmed/26784179
http://dx.doi.org/10.3390/ijms17010110
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