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Structure Prediction: New Insights into Decrypting Long Noncoding RNAs
Long noncoding RNAs (lncRNAs), which form a diverse class of RNAs, remain the least understood type of noncoding RNAs in terms of their nature and identification. Emerging evidence has revealed that a small number of newly discovered lncRNAs perform important and complex biological functions such as...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730372/ https://www.ncbi.nlm.nih.gov/pubmed/26805815 http://dx.doi.org/10.3390/ijms17010132 |
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author | Yan, Kun Arfat, Yasir Li, Dijie Zhao, Fan Chen, Zhihao Yin, Chong Sun, Yulong Hu, Lifang Yang, Tuanmin Qian, Airong |
author_facet | Yan, Kun Arfat, Yasir Li, Dijie Zhao, Fan Chen, Zhihao Yin, Chong Sun, Yulong Hu, Lifang Yang, Tuanmin Qian, Airong |
author_sort | Yan, Kun |
collection | PubMed |
description | Long noncoding RNAs (lncRNAs), which form a diverse class of RNAs, remain the least understood type of noncoding RNAs in terms of their nature and identification. Emerging evidence has revealed that a small number of newly discovered lncRNAs perform important and complex biological functions such as dosage compensation, chromatin regulation, genomic imprinting, and nuclear organization. However, understanding the wide range of functions of lncRNAs related to various processes of cellular networks remains a great experimental challenge. Structural versatility is critical for RNAs to perform various functions and provides new insights into probing the functions of lncRNAs. In recent years, the computational method of RNA structure prediction has been developed to analyze the structure of lncRNAs. This novel methodology has provided basic but indispensable information for the rapid, large-scale and in-depth research of lncRNAs. This review focuses on mainstream RNA structure prediction methods at the secondary and tertiary levels to offer an additional approach to investigating the functions of lncRNAs. |
format | Online Article Text |
id | pubmed-4730372 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-47303722016-02-11 Structure Prediction: New Insights into Decrypting Long Noncoding RNAs Yan, Kun Arfat, Yasir Li, Dijie Zhao, Fan Chen, Zhihao Yin, Chong Sun, Yulong Hu, Lifang Yang, Tuanmin Qian, Airong Int J Mol Sci Review Long noncoding RNAs (lncRNAs), which form a diverse class of RNAs, remain the least understood type of noncoding RNAs in terms of their nature and identification. Emerging evidence has revealed that a small number of newly discovered lncRNAs perform important and complex biological functions such as dosage compensation, chromatin regulation, genomic imprinting, and nuclear organization. However, understanding the wide range of functions of lncRNAs related to various processes of cellular networks remains a great experimental challenge. Structural versatility is critical for RNAs to perform various functions and provides new insights into probing the functions of lncRNAs. In recent years, the computational method of RNA structure prediction has been developed to analyze the structure of lncRNAs. This novel methodology has provided basic but indispensable information for the rapid, large-scale and in-depth research of lncRNAs. This review focuses on mainstream RNA structure prediction methods at the secondary and tertiary levels to offer an additional approach to investigating the functions of lncRNAs. MDPI 2016-01-21 /pmc/articles/PMC4730372/ /pubmed/26805815 http://dx.doi.org/10.3390/ijms17010132 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Yan, Kun Arfat, Yasir Li, Dijie Zhao, Fan Chen, Zhihao Yin, Chong Sun, Yulong Hu, Lifang Yang, Tuanmin Qian, Airong Structure Prediction: New Insights into Decrypting Long Noncoding RNAs |
title | Structure Prediction: New Insights into Decrypting Long Noncoding RNAs |
title_full | Structure Prediction: New Insights into Decrypting Long Noncoding RNAs |
title_fullStr | Structure Prediction: New Insights into Decrypting Long Noncoding RNAs |
title_full_unstemmed | Structure Prediction: New Insights into Decrypting Long Noncoding RNAs |
title_short | Structure Prediction: New Insights into Decrypting Long Noncoding RNAs |
title_sort | structure prediction: new insights into decrypting long noncoding rnas |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730372/ https://www.ncbi.nlm.nih.gov/pubmed/26805815 http://dx.doi.org/10.3390/ijms17010132 |
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