Cargando…

Ethnic Differences in Maternal Adipokines during Normal Pregnancy

Two adipokines (adiponectin and resistin) have opposite relations with insulin resistance and inflammation. Our major focus was to determine whether there were detectable ethnic differences in maternal adipokines during pregnancy. We also explored the correlation of the adipokines with maternal gluc...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Xinhua, Scholl, Theresa O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730399/
https://www.ncbi.nlm.nih.gov/pubmed/26703679
http://dx.doi.org/10.3390/ijerph13010008
_version_ 1782412391316717568
author Chen, Xinhua
Scholl, Theresa O.
author_facet Chen, Xinhua
Scholl, Theresa O.
author_sort Chen, Xinhua
collection PubMed
description Two adipokines (adiponectin and resistin) have opposite relations with insulin resistance and inflammation. Our major focus was to determine whether there were detectable ethnic differences in maternal adipokines during pregnancy. We also explored the correlation of the adipokines with maternal glucose homeostasis, blood pressure and anthropometric parameters. Pregnant women (n = 1634) were from a large prospective cohort study in Camden NJ (African-American 36.8%; Hispanic 47.6%; Caucasian 15.6%). Serum adiponectin and resistin were measured at entry (week 16.8) and the 3rd trimester (week 30.7) using the Luminex xMapTechnology. Significant differences were observed among ethnic groups, controlling for confounding variables. African American women were exceptional in that they had decreased adiponectin and increased resistin throughout the course of pregnancy (p < 0.05 to p < 0.0001) and a greater than two fold risk of simultaneously exhibiting low adiponectin (lowest tertile) and high resistin (highest tertile) compared to Caucasians and/or Hispanics. The cohort as a whole and each ethnic group showed similar negative correlations between adiponectin, and glucose homeostasis, blood pressure and anthropometric parameters but there was lesser correspondence with resistin. Our data underscore the need for further research on ethnic variation in adipokines and other physiologic biomarkers during complicated and uncomplicated pregnancy.
format Online
Article
Text
id pubmed-4730399
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-47303992016-02-11 Ethnic Differences in Maternal Adipokines during Normal Pregnancy Chen, Xinhua Scholl, Theresa O. Int J Environ Res Public Health Article Two adipokines (adiponectin and resistin) have opposite relations with insulin resistance and inflammation. Our major focus was to determine whether there were detectable ethnic differences in maternal adipokines during pregnancy. We also explored the correlation of the adipokines with maternal glucose homeostasis, blood pressure and anthropometric parameters. Pregnant women (n = 1634) were from a large prospective cohort study in Camden NJ (African-American 36.8%; Hispanic 47.6%; Caucasian 15.6%). Serum adiponectin and resistin were measured at entry (week 16.8) and the 3rd trimester (week 30.7) using the Luminex xMapTechnology. Significant differences were observed among ethnic groups, controlling for confounding variables. African American women were exceptional in that they had decreased adiponectin and increased resistin throughout the course of pregnancy (p < 0.05 to p < 0.0001) and a greater than two fold risk of simultaneously exhibiting low adiponectin (lowest tertile) and high resistin (highest tertile) compared to Caucasians and/or Hispanics. The cohort as a whole and each ethnic group showed similar negative correlations between adiponectin, and glucose homeostasis, blood pressure and anthropometric parameters but there was lesser correspondence with resistin. Our data underscore the need for further research on ethnic variation in adipokines and other physiologic biomarkers during complicated and uncomplicated pregnancy. MDPI 2015-12-22 2016-01 /pmc/articles/PMC4730399/ /pubmed/26703679 http://dx.doi.org/10.3390/ijerph13010008 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, Xinhua
Scholl, Theresa O.
Ethnic Differences in Maternal Adipokines during Normal Pregnancy
title Ethnic Differences in Maternal Adipokines during Normal Pregnancy
title_full Ethnic Differences in Maternal Adipokines during Normal Pregnancy
title_fullStr Ethnic Differences in Maternal Adipokines during Normal Pregnancy
title_full_unstemmed Ethnic Differences in Maternal Adipokines during Normal Pregnancy
title_short Ethnic Differences in Maternal Adipokines during Normal Pregnancy
title_sort ethnic differences in maternal adipokines during normal pregnancy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730399/
https://www.ncbi.nlm.nih.gov/pubmed/26703679
http://dx.doi.org/10.3390/ijerph13010008
work_keys_str_mv AT chenxinhua ethnicdifferencesinmaternaladipokinesduringnormalpregnancy
AT scholltheresao ethnicdifferencesinmaternaladipokinesduringnormalpregnancy