Cargando…

The Ala54Thr Polymorphism of the Fatty Acid Binding Protein 2 Gene Modulates HDL Cholesterol in Mexican-Americans with Type 2 Diabetes

The alanine to threonine amino acid substitution at codon 54 (Ala54Thr) of the intestinal fatty acid binding protein (FABP2) has been associated with elevated levels of insulin and blood glucose as well as with dyslipidemia. The aim of this study was to characterize the effect of this FABP2 polymorp...

Descripción completa

Detalles Bibliográficos
Autores principales: Salto, Lorena M., Bu, Liming, Beeson, W. Lawrence, Firek, Anthony, Cordero-MacIntyre, Zaida, De Leon, Marino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730443/
https://www.ncbi.nlm.nih.gov/pubmed/26703680
http://dx.doi.org/10.3390/ijerph13010052
_version_ 1782412401337958400
author Salto, Lorena M.
Bu, Liming
Beeson, W. Lawrence
Firek, Anthony
Cordero-MacIntyre, Zaida
De Leon, Marino
author_facet Salto, Lorena M.
Bu, Liming
Beeson, W. Lawrence
Firek, Anthony
Cordero-MacIntyre, Zaida
De Leon, Marino
author_sort Salto, Lorena M.
collection PubMed
description The alanine to threonine amino acid substitution at codon 54 (Ala54Thr) of the intestinal fatty acid binding protein (FABP2) has been associated with elevated levels of insulin and blood glucose as well as with dyslipidemia. The aim of this study was to characterize the effect of this FABP2 polymorphism in Mexican-Americans with type 2 diabetes (T2D) in the context of a three-month intervention to determine if the polymorphism differentially modulates selected clinical outcomes. For this study, we genotyped 43 participant samples and performed post-hoc outcome analysis of the profile changes in fasting blood glucose, HbA1c, insulin, lipid panel and body composition, stratified by the Ala54Thr polymorphism. Our results show that the Thr54 allele carriers (those who were heterozygous or homozygous for the threonine-encoding allele) had lower HDL cholesterol and higher triglyceride levels at baseline compared to the Ala54 homozygotes (those who were homozygous for the alanine-encoding allele). Both groups made clinically important improvements in lipid profiles and glycemic control as a response to the intervention. Whereas the Ala54 homozygotes decreased HDL cholesterol in the context of an overall total cholesterol decrease, Thr54 allele carriers increased HDL cholesterol as part of an overall total cholesterol decrease. We conclude that the Ala54Thr polymorphism of FABP2 modulates HDL cholesterol in Mexican-Americans with T2D and that Thr54 allele carriers may be responsive in interventions that include dietary changes.
format Online
Article
Text
id pubmed-4730443
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-47304432016-02-11 The Ala54Thr Polymorphism of the Fatty Acid Binding Protein 2 Gene Modulates HDL Cholesterol in Mexican-Americans with Type 2 Diabetes Salto, Lorena M. Bu, Liming Beeson, W. Lawrence Firek, Anthony Cordero-MacIntyre, Zaida De Leon, Marino Int J Environ Res Public Health Article The alanine to threonine amino acid substitution at codon 54 (Ala54Thr) of the intestinal fatty acid binding protein (FABP2) has been associated with elevated levels of insulin and blood glucose as well as with dyslipidemia. The aim of this study was to characterize the effect of this FABP2 polymorphism in Mexican-Americans with type 2 diabetes (T2D) in the context of a three-month intervention to determine if the polymorphism differentially modulates selected clinical outcomes. For this study, we genotyped 43 participant samples and performed post-hoc outcome analysis of the profile changes in fasting blood glucose, HbA1c, insulin, lipid panel and body composition, stratified by the Ala54Thr polymorphism. Our results show that the Thr54 allele carriers (those who were heterozygous or homozygous for the threonine-encoding allele) had lower HDL cholesterol and higher triglyceride levels at baseline compared to the Ala54 homozygotes (those who were homozygous for the alanine-encoding allele). Both groups made clinically important improvements in lipid profiles and glycemic control as a response to the intervention. Whereas the Ala54 homozygotes decreased HDL cholesterol in the context of an overall total cholesterol decrease, Thr54 allele carriers increased HDL cholesterol as part of an overall total cholesterol decrease. We conclude that the Ala54Thr polymorphism of FABP2 modulates HDL cholesterol in Mexican-Americans with T2D and that Thr54 allele carriers may be responsive in interventions that include dietary changes. MDPI 2015-12-23 2016-01 /pmc/articles/PMC4730443/ /pubmed/26703680 http://dx.doi.org/10.3390/ijerph13010052 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Salto, Lorena M.
Bu, Liming
Beeson, W. Lawrence
Firek, Anthony
Cordero-MacIntyre, Zaida
De Leon, Marino
The Ala54Thr Polymorphism of the Fatty Acid Binding Protein 2 Gene Modulates HDL Cholesterol in Mexican-Americans with Type 2 Diabetes
title The Ala54Thr Polymorphism of the Fatty Acid Binding Protein 2 Gene Modulates HDL Cholesterol in Mexican-Americans with Type 2 Diabetes
title_full The Ala54Thr Polymorphism of the Fatty Acid Binding Protein 2 Gene Modulates HDL Cholesterol in Mexican-Americans with Type 2 Diabetes
title_fullStr The Ala54Thr Polymorphism of the Fatty Acid Binding Protein 2 Gene Modulates HDL Cholesterol in Mexican-Americans with Type 2 Diabetes
title_full_unstemmed The Ala54Thr Polymorphism of the Fatty Acid Binding Protein 2 Gene Modulates HDL Cholesterol in Mexican-Americans with Type 2 Diabetes
title_short The Ala54Thr Polymorphism of the Fatty Acid Binding Protein 2 Gene Modulates HDL Cholesterol in Mexican-Americans with Type 2 Diabetes
title_sort ala54thr polymorphism of the fatty acid binding protein 2 gene modulates hdl cholesterol in mexican-americans with type 2 diabetes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730443/
https://www.ncbi.nlm.nih.gov/pubmed/26703680
http://dx.doi.org/10.3390/ijerph13010052
work_keys_str_mv AT saltolorenam theala54thrpolymorphismofthefattyacidbindingprotein2genemodulateshdlcholesterolinmexicanamericanswithtype2diabetes
AT buliming theala54thrpolymorphismofthefattyacidbindingprotein2genemodulateshdlcholesterolinmexicanamericanswithtype2diabetes
AT beesonwlawrence theala54thrpolymorphismofthefattyacidbindingprotein2genemodulateshdlcholesterolinmexicanamericanswithtype2diabetes
AT firekanthony theala54thrpolymorphismofthefattyacidbindingprotein2genemodulateshdlcholesterolinmexicanamericanswithtype2diabetes
AT corderomacintyrezaida theala54thrpolymorphismofthefattyacidbindingprotein2genemodulateshdlcholesterolinmexicanamericanswithtype2diabetes
AT deleonmarino theala54thrpolymorphismofthefattyacidbindingprotein2genemodulateshdlcholesterolinmexicanamericanswithtype2diabetes
AT saltolorenam ala54thrpolymorphismofthefattyacidbindingprotein2genemodulateshdlcholesterolinmexicanamericanswithtype2diabetes
AT buliming ala54thrpolymorphismofthefattyacidbindingprotein2genemodulateshdlcholesterolinmexicanamericanswithtype2diabetes
AT beesonwlawrence ala54thrpolymorphismofthefattyacidbindingprotein2genemodulateshdlcholesterolinmexicanamericanswithtype2diabetes
AT firekanthony ala54thrpolymorphismofthefattyacidbindingprotein2genemodulateshdlcholesterolinmexicanamericanswithtype2diabetes
AT corderomacintyrezaida ala54thrpolymorphismofthefattyacidbindingprotein2genemodulateshdlcholesterolinmexicanamericanswithtype2diabetes
AT deleonmarino ala54thrpolymorphismofthefattyacidbindingprotein2genemodulateshdlcholesterolinmexicanamericanswithtype2diabetes