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Distribution and Predictors of Pesticides in the Umbilical Cord Blood of Chinese Newborns

Rates of pesticide use in Chinese agriculture are five times greater than the global average, leading to high exposure via the diet. Many are neurotoxic, making prenatal pesticide exposure a concern. Previous studies of prenatal exposure in China focused almost entirely on organochlorines. Here the...

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Autores principales: Silver, Monica K., Shao, Jie, Chen, Minjian, Xia, Yankai, Lozoff, Betsy, Meeker, John D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730485/
https://www.ncbi.nlm.nih.gov/pubmed/26729147
http://dx.doi.org/10.3390/ijerph13010094
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author Silver, Monica K.
Shao, Jie
Chen, Minjian
Xia, Yankai
Lozoff, Betsy
Meeker, John D.
author_facet Silver, Monica K.
Shao, Jie
Chen, Minjian
Xia, Yankai
Lozoff, Betsy
Meeker, John D.
author_sort Silver, Monica K.
collection PubMed
description Rates of pesticide use in Chinese agriculture are five times greater than the global average, leading to high exposure via the diet. Many are neurotoxic, making prenatal pesticide exposure a concern. Previous studies of prenatal exposure in China focused almost entirely on organochlorines. Here the study goals were to characterize the exposure of Chinese newborns to all classes of pesticides and identify predictors of those exposures. Eighty-four pesticides and 12 metabolites were measured in the umbilical cord plasma of 336 infants. Composite variables were created for totals detected overall and by class. Individual pesticides were analyzed as dichotomous or continuous, based on detection rates. Relationships between demographic characteristics and pesticides were evaluated using generalized linear regression. Seventy-five pesticides were detected. The mean number of detects per sample was 15.3. Increased pesticide detects were found in the cord blood of infants born in the summer (β = 2.2, p = 0.01), particularly in July (β = 4.0, p = 0.03). Similar trends were observed for individual insecticide classes. Thus, a summer birth was the strongest predictor of pesticide evidence in cord blood. Associations were more striking for overall pesticide exposure than for individual pesticides, highlighting the importance of considering exposure to mixtures of pesticides, rather than individual agents or classes.
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spelling pubmed-47304852016-02-11 Distribution and Predictors of Pesticides in the Umbilical Cord Blood of Chinese Newborns Silver, Monica K. Shao, Jie Chen, Minjian Xia, Yankai Lozoff, Betsy Meeker, John D. Int J Environ Res Public Health Article Rates of pesticide use in Chinese agriculture are five times greater than the global average, leading to high exposure via the diet. Many are neurotoxic, making prenatal pesticide exposure a concern. Previous studies of prenatal exposure in China focused almost entirely on organochlorines. Here the study goals were to characterize the exposure of Chinese newborns to all classes of pesticides and identify predictors of those exposures. Eighty-four pesticides and 12 metabolites were measured in the umbilical cord plasma of 336 infants. Composite variables were created for totals detected overall and by class. Individual pesticides were analyzed as dichotomous or continuous, based on detection rates. Relationships between demographic characteristics and pesticides were evaluated using generalized linear regression. Seventy-five pesticides were detected. The mean number of detects per sample was 15.3. Increased pesticide detects were found in the cord blood of infants born in the summer (β = 2.2, p = 0.01), particularly in July (β = 4.0, p = 0.03). Similar trends were observed for individual insecticide classes. Thus, a summer birth was the strongest predictor of pesticide evidence in cord blood. Associations were more striking for overall pesticide exposure than for individual pesticides, highlighting the importance of considering exposure to mixtures of pesticides, rather than individual agents or classes. MDPI 2015-12-30 2016-01 /pmc/articles/PMC4730485/ /pubmed/26729147 http://dx.doi.org/10.3390/ijerph13010094 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Silver, Monica K.
Shao, Jie
Chen, Minjian
Xia, Yankai
Lozoff, Betsy
Meeker, John D.
Distribution and Predictors of Pesticides in the Umbilical Cord Blood of Chinese Newborns
title Distribution and Predictors of Pesticides in the Umbilical Cord Blood of Chinese Newborns
title_full Distribution and Predictors of Pesticides in the Umbilical Cord Blood of Chinese Newborns
title_fullStr Distribution and Predictors of Pesticides in the Umbilical Cord Blood of Chinese Newborns
title_full_unstemmed Distribution and Predictors of Pesticides in the Umbilical Cord Blood of Chinese Newborns
title_short Distribution and Predictors of Pesticides in the Umbilical Cord Blood of Chinese Newborns
title_sort distribution and predictors of pesticides in the umbilical cord blood of chinese newborns
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730485/
https://www.ncbi.nlm.nih.gov/pubmed/26729147
http://dx.doi.org/10.3390/ijerph13010094
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