Blocking heme oxygenase-1 by zinc protoporphyrin reduces tumor hypoxia-mediated VEGF release and inhibits tumor angiogenesis as a potential therapeutic agent against colorectal cancer

BACKGROUND: Hypoxia in tumor niche is one of important factors to start regeneration of blood vessels, leading to increase survival, proliferation, and invasion in cancer cells. Under hypoxia microenvironment, furthermore, steadily increased hypoxia-inducible factor-1α (HIF-1α) is observed, and can...

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Detalles Bibliográficos
Autores principales: Cheng, Chun-Chia, Guan, Siao-Syun, Yang, Hao-Jhih, Chang, Chun-Chao, Luo, Tsai-Yueh, Chang, Jungshan, Ho, Ai-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730655/
https://www.ncbi.nlm.nih.gov/pubmed/26822586
http://dx.doi.org/10.1186/s12929-016-0219-6

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