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Hemoglobin as a possible biochemical index of hypertension-induced vascular damage

BACKGROUND: We previously reported on the positive association of hemoglobin with hypertension and atherosclerosis. On the other hand, hepatocyte growth factor (HGF) has been evaluated as a possible biochemical index of hypertension-induced vascular damage. However, no studies have reported on a cor...

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Autores principales: Shimizu, Yuji, Kadota, Koichiro, Nakazato, Mio, Noguchi, Yuko, Koyamatsu, Jun, Yamanashi, Hirotomo, Nagayoshi, Mako, Nagata, Shuichi, Arima, Kazuhiko, Maeda, Takahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730762/
https://www.ncbi.nlm.nih.gov/pubmed/26818627
http://dx.doi.org/10.1186/s40101-016-0085-7
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author Shimizu, Yuji
Kadota, Koichiro
Nakazato, Mio
Noguchi, Yuko
Koyamatsu, Jun
Yamanashi, Hirotomo
Nagayoshi, Mako
Nagata, Shuichi
Arima, Kazuhiko
Maeda, Takahiro
author_facet Shimizu, Yuji
Kadota, Koichiro
Nakazato, Mio
Noguchi, Yuko
Koyamatsu, Jun
Yamanashi, Hirotomo
Nagayoshi, Mako
Nagata, Shuichi
Arima, Kazuhiko
Maeda, Takahiro
author_sort Shimizu, Yuji
collection PubMed
description BACKGROUND: We previously reported on the positive association of hemoglobin with hypertension and atherosclerosis. On the other hand, hepatocyte growth factor (HGF) has been evaluated as a possible biochemical index of hypertension-induced vascular damage. However, no studies have reported on a correlation between hemoglobin and HGF accounting for hypertension status. METHODS: A cross-sectional study of 1108 subjects (392 men and 716 women, 40–93 years old) who were undergoing a general checkup in 2014 was conducted. RESULTS: Multiple linear regression analysis adjustment for known cardiovascular risk factors showed no significant correlation between hemoglobin and HGF in non-hypertensive subjects, but a significant positive correlation in hypertensive subjects; β (parameter estimate) = 0.3 (p = 0.975) for non-hypertensive men, β = 0.4 (p = 0.925) for non-hypertensive women, β = 32.7 (p < 0.001) for hypertensive men, and β = 18.7 (p = 0.002) for hypertensive women. CONCLUSION: We found a significant positive correlation between hemoglobin and HGF among hypertensive men and women. Like HGF, hemoglobin may be a useful indicator to evaluate hypertension-induced vascular damage. Since hemoglobin can easily be measured, these results support hemoglobin as an efficient tool to evaluate vascular damage induced by hypertension in daily medical practice.
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spelling pubmed-47307622016-01-29 Hemoglobin as a possible biochemical index of hypertension-induced vascular damage Shimizu, Yuji Kadota, Koichiro Nakazato, Mio Noguchi, Yuko Koyamatsu, Jun Yamanashi, Hirotomo Nagayoshi, Mako Nagata, Shuichi Arima, Kazuhiko Maeda, Takahiro J Physiol Anthropol Original Article BACKGROUND: We previously reported on the positive association of hemoglobin with hypertension and atherosclerosis. On the other hand, hepatocyte growth factor (HGF) has been evaluated as a possible biochemical index of hypertension-induced vascular damage. However, no studies have reported on a correlation between hemoglobin and HGF accounting for hypertension status. METHODS: A cross-sectional study of 1108 subjects (392 men and 716 women, 40–93 years old) who were undergoing a general checkup in 2014 was conducted. RESULTS: Multiple linear regression analysis adjustment for known cardiovascular risk factors showed no significant correlation between hemoglobin and HGF in non-hypertensive subjects, but a significant positive correlation in hypertensive subjects; β (parameter estimate) = 0.3 (p = 0.975) for non-hypertensive men, β = 0.4 (p = 0.925) for non-hypertensive women, β = 32.7 (p < 0.001) for hypertensive men, and β = 18.7 (p = 0.002) for hypertensive women. CONCLUSION: We found a significant positive correlation between hemoglobin and HGF among hypertensive men and women. Like HGF, hemoglobin may be a useful indicator to evaluate hypertension-induced vascular damage. Since hemoglobin can easily be measured, these results support hemoglobin as an efficient tool to evaluate vascular damage induced by hypertension in daily medical practice. BioMed Central 2016-01-28 /pmc/articles/PMC4730762/ /pubmed/26818627 http://dx.doi.org/10.1186/s40101-016-0085-7 Text en © Shimizu et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Original Article
Shimizu, Yuji
Kadota, Koichiro
Nakazato, Mio
Noguchi, Yuko
Koyamatsu, Jun
Yamanashi, Hirotomo
Nagayoshi, Mako
Nagata, Shuichi
Arima, Kazuhiko
Maeda, Takahiro
Hemoglobin as a possible biochemical index of hypertension-induced vascular damage
title Hemoglobin as a possible biochemical index of hypertension-induced vascular damage
title_full Hemoglobin as a possible biochemical index of hypertension-induced vascular damage
title_fullStr Hemoglobin as a possible biochemical index of hypertension-induced vascular damage
title_full_unstemmed Hemoglobin as a possible biochemical index of hypertension-induced vascular damage
title_short Hemoglobin as a possible biochemical index of hypertension-induced vascular damage
title_sort hemoglobin as a possible biochemical index of hypertension-induced vascular damage
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730762/
https://www.ncbi.nlm.nih.gov/pubmed/26818627
http://dx.doi.org/10.1186/s40101-016-0085-7
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