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Lycium barbarum polysaccharides promotes in vivo proliferation of adult rat retinal progenitor cells
Lycium barbarum is a widely used Chinese herbal medicine prescription for protection of optic nerve. However, it remains unclear regarding the effects of Lycium barbarum polysaccharides, the main component of Lycium barbarum, on in vivo proliferation of adult ciliary body cells. In this study, adult...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730821/ https://www.ncbi.nlm.nih.gov/pubmed/26889185 http://dx.doi.org/10.4103/1673-5374.172315 |
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author | Wang, Hua Lau, Benson Wui-Man Wang, Ning-li Wang, Si-ying Lu, Qing-jun Chang, Raymond Chuen-Chung So, Kwok-fai |
author_facet | Wang, Hua Lau, Benson Wui-Man Wang, Ning-li Wang, Si-ying Lu, Qing-jun Chang, Raymond Chuen-Chung So, Kwok-fai |
author_sort | Wang, Hua |
collection | PubMed |
description | Lycium barbarum is a widely used Chinese herbal medicine prescription for protection of optic nerve. However, it remains unclear regarding the effects of Lycium barbarum polysaccharides, the main component of Lycium barbarum, on in vivo proliferation of adult ciliary body cells. In this study, adult rats were intragastrically administered low- and high-dose Lycium barbarum polysaccharides (1 and 10 mg/kg) for 35 days and those intragastrically administered phosphate buffered saline served as controls. The number of Ki-67-positive cells in rat ciliary body in the Lycium barbarum polysaccharides groups, in particular low-dose Lycium barbarum polysaccharides group, was significantly greater than that in the phosphate buffered saline group. Ki-67-positive rat ciliary body cells expressed nestin but they did not express glial fibrillary acidic protein. These findings suggest that Lycium barbarum polysaccharides can promote the proliferation of adult rat retinal progenitor cells and the proliferated cells present with neuronal phenotype. |
format | Online Article Text |
id | pubmed-4730821 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-47308212016-02-17 Lycium barbarum polysaccharides promotes in vivo proliferation of adult rat retinal progenitor cells Wang, Hua Lau, Benson Wui-Man Wang, Ning-li Wang, Si-ying Lu, Qing-jun Chang, Raymond Chuen-Chung So, Kwok-fai Neural Regen Res Research Article Lycium barbarum is a widely used Chinese herbal medicine prescription for protection of optic nerve. However, it remains unclear regarding the effects of Lycium barbarum polysaccharides, the main component of Lycium barbarum, on in vivo proliferation of adult ciliary body cells. In this study, adult rats were intragastrically administered low- and high-dose Lycium barbarum polysaccharides (1 and 10 mg/kg) for 35 days and those intragastrically administered phosphate buffered saline served as controls. The number of Ki-67-positive cells in rat ciliary body in the Lycium barbarum polysaccharides groups, in particular low-dose Lycium barbarum polysaccharides group, was significantly greater than that in the phosphate buffered saline group. Ki-67-positive rat ciliary body cells expressed nestin but they did not express glial fibrillary acidic protein. These findings suggest that Lycium barbarum polysaccharides can promote the proliferation of adult rat retinal progenitor cells and the proliferated cells present with neuronal phenotype. Medknow Publications & Media Pvt Ltd 2015-12 /pmc/articles/PMC4730821/ /pubmed/26889185 http://dx.doi.org/10.4103/1673-5374.172315 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Research Article Wang, Hua Lau, Benson Wui-Man Wang, Ning-li Wang, Si-ying Lu, Qing-jun Chang, Raymond Chuen-Chung So, Kwok-fai Lycium barbarum polysaccharides promotes in vivo proliferation of adult rat retinal progenitor cells |
title | Lycium barbarum polysaccharides promotes in vivo proliferation of adult rat retinal progenitor cells |
title_full | Lycium barbarum polysaccharides promotes in vivo proliferation of adult rat retinal progenitor cells |
title_fullStr | Lycium barbarum polysaccharides promotes in vivo proliferation of adult rat retinal progenitor cells |
title_full_unstemmed | Lycium barbarum polysaccharides promotes in vivo proliferation of adult rat retinal progenitor cells |
title_short | Lycium barbarum polysaccharides promotes in vivo proliferation of adult rat retinal progenitor cells |
title_sort | lycium barbarum polysaccharides promotes in vivo proliferation of adult rat retinal progenitor cells |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730821/ https://www.ncbi.nlm.nih.gov/pubmed/26889185 http://dx.doi.org/10.4103/1673-5374.172315 |
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