Synthesis and activity of a novel inhibitor of nonsense-mediated mRNA decay

During efforts to prepare the known compound NMDI1, a new tetracyclic compound, called VG1, was prepared in six steps. This compound was found to have good activity as an inhibitor of nonsense-mediated mRNA decay.

Detalles Bibliográficos
Autores principales: Gotham, Victoria J. B., Hobbs, Melanie C., Burgin, Ryan, Turton, David, Smythe, Carl, Coldham, Iain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730866/
https://www.ncbi.nlm.nih.gov/pubmed/26740124
http://dx.doi.org/10.1039/c5ob02482j
Descripción
Sumario:During efforts to prepare the known compound NMDI1, a new tetracyclic compound, called VG1, was prepared in six steps. This compound was found to have good activity as an inhibitor of nonsense-mediated mRNA decay.

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