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Arterial Stiffness, Distensibility, and Strain in Asthmatic Children

BACKGROUND: We hypothesized that since asthma is a chronic inflammatory disease, it could lead to the early development of atherosclerosis in childhood-onset asthma. The aim of this study was to investigate arterial stiffness, distensibility, and strain of different peripheral arteries, the paramete...

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Autores principales: Özkan, Esra Akyüz, Serin, Halil İbrahim, Khosroshahi, Hashem E., Kılıç, Mahmut, Ekim, Meral, Beysel, Perihan, Geçit, U. Aliye, Domur, Esra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731016/
https://www.ncbi.nlm.nih.gov/pubmed/26803723
http://dx.doi.org/10.12659/MSM.895502
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author Özkan, Esra Akyüz
Serin, Halil İbrahim
Khosroshahi, Hashem E.
Kılıç, Mahmut
Ekim, Meral
Beysel, Perihan
Geçit, U. Aliye
Domur, Esra
author_facet Özkan, Esra Akyüz
Serin, Halil İbrahim
Khosroshahi, Hashem E.
Kılıç, Mahmut
Ekim, Meral
Beysel, Perihan
Geçit, U. Aliye
Domur, Esra
author_sort Özkan, Esra Akyüz
collection PubMed
description BACKGROUND: We hypothesized that since asthma is a chronic inflammatory disease, it could lead to the early development of atherosclerosis in childhood-onset asthma. The aim of this study was to investigate arterial stiffness, distensibility, and strain of different peripheral arteries, the parameters of which can be used to detect atherosclerosis in asthmatic children. MATERIAL/METHODS: We studied 22 pediatric patients with asthma and 18 healthy children. Fasting blood glucose and cholesterol levels were evaluated to exclude children with diabetes and hyperlipidemia, which are risk factors for atherosclerosis. Renal, carotid, and brachial arteries diameters were measured. Using the measured data, stiffness, distensibility, and strain of the arteries of all children were calculated. RESULTS: Pulse pressure, systolic and diastolic blood pressure, heart rate, cholesterols, and glucose levels of the obese individuals were similar to the controls. In carotid arteries there were no statistical differences regarding stiffness, distensibility, and strain. According to multiple ANCOVA analysis, distensibility and strain of right and left brachial arteries and right renal artery were higher, whereas right renal artery stiffness was lower in asthmatic children than in controls. Approximately one-fifth of the change in the left and right brachial arteries and right renal artery distensibility and strain and a small portion of the change in the right renal artery stiffness were associated with asthma. In contrast, left renal artery distensibility, strain, and stiffness were not associated with asthma. CONCLUSIONS: Peripheral arteries had higher distensibility and strain, and lower stiffness in asthmatic children than in controls.
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spelling pubmed-47310162016-02-03 Arterial Stiffness, Distensibility, and Strain in Asthmatic Children Özkan, Esra Akyüz Serin, Halil İbrahim Khosroshahi, Hashem E. Kılıç, Mahmut Ekim, Meral Beysel, Perihan Geçit, U. Aliye Domur, Esra Med Sci Monit Clinical Research BACKGROUND: We hypothesized that since asthma is a chronic inflammatory disease, it could lead to the early development of atherosclerosis in childhood-onset asthma. The aim of this study was to investigate arterial stiffness, distensibility, and strain of different peripheral arteries, the parameters of which can be used to detect atherosclerosis in asthmatic children. MATERIAL/METHODS: We studied 22 pediatric patients with asthma and 18 healthy children. Fasting blood glucose and cholesterol levels were evaluated to exclude children with diabetes and hyperlipidemia, which are risk factors for atherosclerosis. Renal, carotid, and brachial arteries diameters were measured. Using the measured data, stiffness, distensibility, and strain of the arteries of all children were calculated. RESULTS: Pulse pressure, systolic and diastolic blood pressure, heart rate, cholesterols, and glucose levels of the obese individuals were similar to the controls. In carotid arteries there were no statistical differences regarding stiffness, distensibility, and strain. According to multiple ANCOVA analysis, distensibility and strain of right and left brachial arteries and right renal artery were higher, whereas right renal artery stiffness was lower in asthmatic children than in controls. Approximately one-fifth of the change in the left and right brachial arteries and right renal artery distensibility and strain and a small portion of the change in the right renal artery stiffness were associated with asthma. In contrast, left renal artery distensibility, strain, and stiffness were not associated with asthma. CONCLUSIONS: Peripheral arteries had higher distensibility and strain, and lower stiffness in asthmatic children than in controls. International Scientific Literature, Inc. 2016-01-24 /pmc/articles/PMC4731016/ /pubmed/26803723 http://dx.doi.org/10.12659/MSM.895502 Text en © Med Sci Monit, 2016 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License
spellingShingle Clinical Research
Özkan, Esra Akyüz
Serin, Halil İbrahim
Khosroshahi, Hashem E.
Kılıç, Mahmut
Ekim, Meral
Beysel, Perihan
Geçit, U. Aliye
Domur, Esra
Arterial Stiffness, Distensibility, and Strain in Asthmatic Children
title Arterial Stiffness, Distensibility, and Strain in Asthmatic Children
title_full Arterial Stiffness, Distensibility, and Strain in Asthmatic Children
title_fullStr Arterial Stiffness, Distensibility, and Strain in Asthmatic Children
title_full_unstemmed Arterial Stiffness, Distensibility, and Strain in Asthmatic Children
title_short Arterial Stiffness, Distensibility, and Strain in Asthmatic Children
title_sort arterial stiffness, distensibility, and strain in asthmatic children
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731016/
https://www.ncbi.nlm.nih.gov/pubmed/26803723
http://dx.doi.org/10.12659/MSM.895502
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