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Does High-Dose Antimicrobial Chemotherapy Prevent the Evolution of Resistance?
High-dose chemotherapy has long been advocated as a means of controlling drug resistance in infectious diseases but recent empirical studies have begun to challenge this view. We develop a very general framework for modeling and understanding resistance emergence based on principles from evolutionar...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731197/ https://www.ncbi.nlm.nih.gov/pubmed/26820986 http://dx.doi.org/10.1371/journal.pcbi.1004689 |