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Intravoxel Incoherent Motion MR Imaging for Staging of Hepatic Fibrosis
OBJECTIVES: To determine the potential of intravoxel incoherent motion (IVIM) MR imaging for staging of hepatic fibrosis (HF). METHODS: We searched PubMed and EMBASE from their inception to 31 July 2015 to select studies reporting IVIM MR imaging and HF staging. We defined F1-2 as non-advanced HF, F...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731200/ https://www.ncbi.nlm.nih.gov/pubmed/26820668 http://dx.doi.org/10.1371/journal.pone.0147789 |
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author | Zhang, Bin Liang, Long Dong, Yuhao Lian, Zhouyang Chen, Wenbo Liang, Changhong Zhang, Shuixing |
author_facet | Zhang, Bin Liang, Long Dong, Yuhao Lian, Zhouyang Chen, Wenbo Liang, Changhong Zhang, Shuixing |
author_sort | Zhang, Bin |
collection | PubMed |
description | OBJECTIVES: To determine the potential of intravoxel incoherent motion (IVIM) MR imaging for staging of hepatic fibrosis (HF). METHODS: We searched PubMed and EMBASE from their inception to 31 July 2015 to select studies reporting IVIM MR imaging and HF staging. We defined F1-2 as non-advanced HF, F3-4 as advanced HF, F0 as normal liver, F1 as very early HF, and F2-4 as significant HF. Then we compared stage F0 with F1, F0-1 with F2-3, and F1-2 with F3-4 using IVIM-derived parameters (pseudo-diffusion coefficient D*, perfusion fraction f, and pure molecular diffusion parameter D). The effect estimate was expressed as a pooled weighted mean difference (WMD) with 95% confidence interval (CI), using the fixed-effects model. RESULTS: Overall, we included six papers (406 patients) in this study. Significant differences in D* were observed between F0 and F1, F0-1 and F2-3, and F1-2 and F3-4 (WMD 2.46, 95% CI 0.83–4.09, P = 0.006; WMD 13.10, 95% CI 9.53–16.67, P < 0.001; WMD 14.34, 95% CI 10.26–18.42, P < 0.001, respectively). Significant differences in f were also found between F0 and F1, F0-1 and F2-3, and F1-2 and F3-4 (WMD 1.62, 95% CI 0.06–3.18, P = 0.027; WMD 5.63, 95% CI 2.74–8.52, P < 0.001; WMD 3.30, 95% CI 2.10–4.50, P < 0.001, respectively). However, D showed no differences between F0 and F1, F0-1 and F2-3, and F1-2 and F3-4 (WMD 0.05, 95% CI -0.01─0.11, P = 0.105; WMD 0.04, 95% CI -0.01─0.10, P = 0.230; WMD 0.02, 95% CI -0.02─0.06, P = 0.378, respectively). CONCLUSIONS: IVIM MR imaging provides an effective method of staging HF and can distinguish early HF from normal liver, significant HF from normal liver or very early HF, and advanced HF from non-advanced HF. |
format | Online Article Text |
id | pubmed-4731200 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-47312002016-02-04 Intravoxel Incoherent Motion MR Imaging for Staging of Hepatic Fibrosis Zhang, Bin Liang, Long Dong, Yuhao Lian, Zhouyang Chen, Wenbo Liang, Changhong Zhang, Shuixing PLoS One Research Article OBJECTIVES: To determine the potential of intravoxel incoherent motion (IVIM) MR imaging for staging of hepatic fibrosis (HF). METHODS: We searched PubMed and EMBASE from their inception to 31 July 2015 to select studies reporting IVIM MR imaging and HF staging. We defined F1-2 as non-advanced HF, F3-4 as advanced HF, F0 as normal liver, F1 as very early HF, and F2-4 as significant HF. Then we compared stage F0 with F1, F0-1 with F2-3, and F1-2 with F3-4 using IVIM-derived parameters (pseudo-diffusion coefficient D*, perfusion fraction f, and pure molecular diffusion parameter D). The effect estimate was expressed as a pooled weighted mean difference (WMD) with 95% confidence interval (CI), using the fixed-effects model. RESULTS: Overall, we included six papers (406 patients) in this study. Significant differences in D* were observed between F0 and F1, F0-1 and F2-3, and F1-2 and F3-4 (WMD 2.46, 95% CI 0.83–4.09, P = 0.006; WMD 13.10, 95% CI 9.53–16.67, P < 0.001; WMD 14.34, 95% CI 10.26–18.42, P < 0.001, respectively). Significant differences in f were also found between F0 and F1, F0-1 and F2-3, and F1-2 and F3-4 (WMD 1.62, 95% CI 0.06–3.18, P = 0.027; WMD 5.63, 95% CI 2.74–8.52, P < 0.001; WMD 3.30, 95% CI 2.10–4.50, P < 0.001, respectively). However, D showed no differences between F0 and F1, F0-1 and F2-3, and F1-2 and F3-4 (WMD 0.05, 95% CI -0.01─0.11, P = 0.105; WMD 0.04, 95% CI -0.01─0.10, P = 0.230; WMD 0.02, 95% CI -0.02─0.06, P = 0.378, respectively). CONCLUSIONS: IVIM MR imaging provides an effective method of staging HF and can distinguish early HF from normal liver, significant HF from normal liver or very early HF, and advanced HF from non-advanced HF. Public Library of Science 2016-01-28 /pmc/articles/PMC4731200/ /pubmed/26820668 http://dx.doi.org/10.1371/journal.pone.0147789 Text en © 2016 Zhang et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Zhang, Bin Liang, Long Dong, Yuhao Lian, Zhouyang Chen, Wenbo Liang, Changhong Zhang, Shuixing Intravoxel Incoherent Motion MR Imaging for Staging of Hepatic Fibrosis |
title | Intravoxel Incoherent Motion MR Imaging for Staging of Hepatic Fibrosis |
title_full | Intravoxel Incoherent Motion MR Imaging for Staging of Hepatic Fibrosis |
title_fullStr | Intravoxel Incoherent Motion MR Imaging for Staging of Hepatic Fibrosis |
title_full_unstemmed | Intravoxel Incoherent Motion MR Imaging for Staging of Hepatic Fibrosis |
title_short | Intravoxel Incoherent Motion MR Imaging for Staging of Hepatic Fibrosis |
title_sort | intravoxel incoherent motion mr imaging for staging of hepatic fibrosis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731200/ https://www.ncbi.nlm.nih.gov/pubmed/26820668 http://dx.doi.org/10.1371/journal.pone.0147789 |
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