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Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open angle glaucoma
Primary open angle glaucoma (POAG) is a leading cause of blindness world-wide. To identify new susceptibility loci, we meta-analyzed GWAS results from 8 independent studies from the United States (3,853 cases and 33,480 controls) and investigated the most significant SNPs in two Australian studies (...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731307/ https://www.ncbi.nlm.nih.gov/pubmed/26752265 http://dx.doi.org/10.1038/ng.3482 |
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| author | Cooke Bailey, Jessica N. Loomis, Stephanie J. Kang, Jae H. Allingham, R. Rand Gharahkhani, Puya Khor, Chiea Chuen Burdon, Kathryn P. Aschard, Hugues Chasman, Daniel I. Igo, Robert P. Hysi, Pirro G. Glastonbury, Craig A. Ashley-Koch, Allison Brilliant, Murray Brown, Andrew A. Budenz, Donald L. Buil, Alfonso Cheng, Ching-Yu Choi, Hyon Christen, William G. Curhan, Gary De Vivo, Immaculata Fingert, John H. Foster, Paul J. Fuchs, Charles Gaasterland, Douglas Gaasterland, Terry Hewitt, Alex W. Hu, Frank Hunter, David J. Khawaja, Anthony P. Lee, Richard K. Li, Zheng Lichter, Paul R. Mackey, David A. McGuffin, Peter Mitchell, Paul Moroi, Sayoko E. Perera, Shamira A. Pepper, Keating W. Qi, Qibin Realini, Tony Richards, Julia E. Ridker, Paul M Rimm, Eric Ritch, Robert Ritchie, Marylyn Schuman, Joel S. Scott, William K. Singh, Kuldev Sit, Arthur J. Song, Yeunjoo E. Tamimi, Rulla M. Topouzis, Fotis Viswanathan, Ananth C. Verma, Shefali Setia Vollrath, Douglas Wang, Jie Jin Weisschuh, Nicole Wissinger, Bernd Wollstein, Gadi Wong, Tien Y. Yaspan, Brian L. Zack, Donald J. Zhang, Kang Weinreb, Robert N. Pericak-Vance, Margaret A. Small, Kerrin Hammond, Christopher J. Aung, Tin Liu, Yutao Vithana, Eranga N. MacGregor, Stuart Craig, Jamie E. Kraft, Peter Howell, Gareth Hauser, Michael A. Pasquale, Louis R. Haines, Jonathan L. Wiggs, Janey L. |
| author_facet | Cooke Bailey, Jessica N. Loomis, Stephanie J. Kang, Jae H. Allingham, R. Rand Gharahkhani, Puya Khor, Chiea Chuen Burdon, Kathryn P. Aschard, Hugues Chasman, Daniel I. Igo, Robert P. Hysi, Pirro G. Glastonbury, Craig A. Ashley-Koch, Allison Brilliant, Murray Brown, Andrew A. Budenz, Donald L. Buil, Alfonso Cheng, Ching-Yu Choi, Hyon Christen, William G. Curhan, Gary De Vivo, Immaculata Fingert, John H. Foster, Paul J. Fuchs, Charles Gaasterland, Douglas Gaasterland, Terry Hewitt, Alex W. Hu, Frank Hunter, David J. Khawaja, Anthony P. Lee, Richard K. Li, Zheng Lichter, Paul R. Mackey, David A. McGuffin, Peter Mitchell, Paul Moroi, Sayoko E. Perera, Shamira A. Pepper, Keating W. Qi, Qibin Realini, Tony Richards, Julia E. Ridker, Paul M Rimm, Eric Ritch, Robert Ritchie, Marylyn Schuman, Joel S. Scott, William K. Singh, Kuldev Sit, Arthur J. Song, Yeunjoo E. Tamimi, Rulla M. Topouzis, Fotis Viswanathan, Ananth C. Verma, Shefali Setia Vollrath, Douglas Wang, Jie Jin Weisschuh, Nicole Wissinger, Bernd Wollstein, Gadi Wong, Tien Y. Yaspan, Brian L. Zack, Donald J. Zhang, Kang Weinreb, Robert N. Pericak-Vance, Margaret A. Small, Kerrin Hammond, Christopher J. Aung, Tin Liu, Yutao Vithana, Eranga N. MacGregor, Stuart Craig, Jamie E. Kraft, Peter Howell, Gareth Hauser, Michael A. Pasquale, Louis R. Haines, Jonathan L. Wiggs, Janey L. |
| author_sort | Cooke Bailey, Jessica N. |
| collection | PubMed |
| description | Primary open angle glaucoma (POAG) is a leading cause of blindness world-wide. To identify new susceptibility loci, we meta-analyzed GWAS results from 8 independent studies from the United States (3,853 cases and 33,480 controls) and investigated the most significant SNPs in two Australian studies (1,252 cases and 2,592 controls), 3 European studies (875 cases and 4,107 controls) and a Singaporean Chinese study (1,037 cases and 2,543 controls). A meta-analysis of top SNPs identified three novel loci: rs35934224[T] within TXNRD2 (odds ratio (OR) = 0.78, P = 4.05×10(−11) encoding a mitochondrial protein required for redox homeostasis; rs7137828[T] within ATXN2 (OR = 1.17, P = 8.73×10(−10)), and rs2745572[A] upstream of FOXC1 (OR = 1.17, P = 1.76×10(−10)). Using RT-PCR and immunohistochemistry, we show TXNRD2 and ATXN2 expression in retinal ganglion cells and the optic nerve head. These results identify new pathways underlying POAG susceptibility and suggest novel targets for preventative therapies. |
| format | Online Article Text |
| id | pubmed-4731307 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2016 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-47313072016-07-11 Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open angle glaucoma Cooke Bailey, Jessica N. Loomis, Stephanie J. Kang, Jae H. Allingham, R. Rand Gharahkhani, Puya Khor, Chiea Chuen Burdon, Kathryn P. Aschard, Hugues Chasman, Daniel I. Igo, Robert P. Hysi, Pirro G. Glastonbury, Craig A. Ashley-Koch, Allison Brilliant, Murray Brown, Andrew A. Budenz, Donald L. Buil, Alfonso Cheng, Ching-Yu Choi, Hyon Christen, William G. Curhan, Gary De Vivo, Immaculata Fingert, John H. Foster, Paul J. Fuchs, Charles Gaasterland, Douglas Gaasterland, Terry Hewitt, Alex W. Hu, Frank Hunter, David J. Khawaja, Anthony P. Lee, Richard K. Li, Zheng Lichter, Paul R. Mackey, David A. McGuffin, Peter Mitchell, Paul Moroi, Sayoko E. Perera, Shamira A. Pepper, Keating W. Qi, Qibin Realini, Tony Richards, Julia E. Ridker, Paul M Rimm, Eric Ritch, Robert Ritchie, Marylyn Schuman, Joel S. Scott, William K. Singh, Kuldev Sit, Arthur J. Song, Yeunjoo E. Tamimi, Rulla M. Topouzis, Fotis Viswanathan, Ananth C. Verma, Shefali Setia Vollrath, Douglas Wang, Jie Jin Weisschuh, Nicole Wissinger, Bernd Wollstein, Gadi Wong, Tien Y. Yaspan, Brian L. Zack, Donald J. Zhang, Kang Weinreb, Robert N. Pericak-Vance, Margaret A. Small, Kerrin Hammond, Christopher J. Aung, Tin Liu, Yutao Vithana, Eranga N. MacGregor, Stuart Craig, Jamie E. Kraft, Peter Howell, Gareth Hauser, Michael A. Pasquale, Louis R. Haines, Jonathan L. Wiggs, Janey L. Nat Genet Article Primary open angle glaucoma (POAG) is a leading cause of blindness world-wide. To identify new susceptibility loci, we meta-analyzed GWAS results from 8 independent studies from the United States (3,853 cases and 33,480 controls) and investigated the most significant SNPs in two Australian studies (1,252 cases and 2,592 controls), 3 European studies (875 cases and 4,107 controls) and a Singaporean Chinese study (1,037 cases and 2,543 controls). A meta-analysis of top SNPs identified three novel loci: rs35934224[T] within TXNRD2 (odds ratio (OR) = 0.78, P = 4.05×10(−11) encoding a mitochondrial protein required for redox homeostasis; rs7137828[T] within ATXN2 (OR = 1.17, P = 8.73×10(−10)), and rs2745572[A] upstream of FOXC1 (OR = 1.17, P = 1.76×10(−10)). Using RT-PCR and immunohistochemistry, we show TXNRD2 and ATXN2 expression in retinal ganglion cells and the optic nerve head. These results identify new pathways underlying POAG susceptibility and suggest novel targets for preventative therapies. 2016-01-11 2016-02 /pmc/articles/PMC4731307/ /pubmed/26752265 http://dx.doi.org/10.1038/ng.3482 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Cooke Bailey, Jessica N. Loomis, Stephanie J. Kang, Jae H. Allingham, R. Rand Gharahkhani, Puya Khor, Chiea Chuen Burdon, Kathryn P. Aschard, Hugues Chasman, Daniel I. Igo, Robert P. Hysi, Pirro G. Glastonbury, Craig A. Ashley-Koch, Allison Brilliant, Murray Brown, Andrew A. Budenz, Donald L. Buil, Alfonso Cheng, Ching-Yu Choi, Hyon Christen, William G. Curhan, Gary De Vivo, Immaculata Fingert, John H. Foster, Paul J. Fuchs, Charles Gaasterland, Douglas Gaasterland, Terry Hewitt, Alex W. Hu, Frank Hunter, David J. Khawaja, Anthony P. Lee, Richard K. Li, Zheng Lichter, Paul R. Mackey, David A. McGuffin, Peter Mitchell, Paul Moroi, Sayoko E. Perera, Shamira A. Pepper, Keating W. Qi, Qibin Realini, Tony Richards, Julia E. Ridker, Paul M Rimm, Eric Ritch, Robert Ritchie, Marylyn Schuman, Joel S. Scott, William K. Singh, Kuldev Sit, Arthur J. Song, Yeunjoo E. Tamimi, Rulla M. Topouzis, Fotis Viswanathan, Ananth C. Verma, Shefali Setia Vollrath, Douglas Wang, Jie Jin Weisschuh, Nicole Wissinger, Bernd Wollstein, Gadi Wong, Tien Y. Yaspan, Brian L. Zack, Donald J. Zhang, Kang Weinreb, Robert N. Pericak-Vance, Margaret A. Small, Kerrin Hammond, Christopher J. Aung, Tin Liu, Yutao Vithana, Eranga N. MacGregor, Stuart Craig, Jamie E. Kraft, Peter Howell, Gareth Hauser, Michael A. Pasquale, Louis R. Haines, Jonathan L. Wiggs, Janey L. Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open angle glaucoma |
| title | Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open angle glaucoma |
| title_full | Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open angle glaucoma |
| title_fullStr | Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open angle glaucoma |
| title_full_unstemmed | Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open angle glaucoma |
| title_short | Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open angle glaucoma |
| title_sort | genome-wide association analysis identifies txnrd2, atxn2 and foxc1 as susceptibility loci for primary open angle glaucoma |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731307/ https://www.ncbi.nlm.nih.gov/pubmed/26752265 http://dx.doi.org/10.1038/ng.3482 |
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