Analysis of Lymphocytic DNA Damage in Early Multiple Sclerosis by Automated Gamma-H2AX and 53BP1 Foci Detection: A Case Control Study

BACKGROUND: In response to DNA double-strand breaks, the histone protein H2AX becomes phosphorylated at its C-terminal serine 139 residue, referred to as γ-H2AX. Formation of γ-H2AX foci is associated with recruitment of p53-binding protein 1 (53BP1), a regulator of the cellular response to DNA doub...

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Detalles Bibliográficos
Autores principales: Rasche, Ludwig, Heiserich, Lisa, Behrens, Janina Ruth, Lenz, Klaus, Pfuhl, Catherina, Wakonig, Katharina, Gieß, René Markus, Freitag, Erik, Eberle, Caroline, Wuerfel, Jens, Dörr, Jan, Bauer, Peter, Bellmann-Strobl, Judith, Paul, Friedemann, Roggenbuck, Dirk, Ruprecht, Klemens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731473/
https://www.ncbi.nlm.nih.gov/pubmed/26820970
http://dx.doi.org/10.1371/journal.pone.0147968

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