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Childhood allergic bronchopulmonary aspergillosis presenting as a middle lobe syndrome

Allergic bronchopulmonary aspergillosis (ABPA) is infrequently documented in children with asthma. Although collapse is not uncommon, middle lobe syndrome (MLS) as a presentation of ABPA is rather a rarity. A 9-year-old female child with asthma presented with increase in intensity of symptoms along...

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Autores principales: Shah, Ashok, Gera, Kamal, Panjabi, Chandramani
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Asia Pacific Association of Allergy, Asthma and Clinical Immunology 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731483/
https://www.ncbi.nlm.nih.gov/pubmed/26844222
http://dx.doi.org/10.5415/apallergy.2016.6.1.67
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author Shah, Ashok
Gera, Kamal
Panjabi, Chandramani
author_facet Shah, Ashok
Gera, Kamal
Panjabi, Chandramani
author_sort Shah, Ashok
collection PubMed
description Allergic bronchopulmonary aspergillosis (ABPA) is infrequently documented in children with asthma. Although collapse is not uncommon, middle lobe syndrome (MLS) as a presentation of ABPA is rather a rarity. A 9-year-old female child with asthma presented with increase in intensity of symptoms along with a right midzone patchy consolidation on a chest radiograph. In addition, an ill-defined opacity abutting the right cardiac border with loss of cardiac silhouette was noted. A right lateral view confirmed a MLS, which was further corroborated by high resolution computed tomography. Central bronchiectasis was also observed, which prompted a work-up for ABPA. The child met 7/8 major diagnostic criteria for ABPA. She was then initiated on oral prednisolone that resulted in a marked clinical improvement within a fortnight. Radiological clearance occurred at 3 months with inflation of the middle lobe. ABPA presenting with MLS in a child is yet to be reported. A high index of suspicion is required to establish the diagnosis of ABPA in a child presenting with MLS. This would obviate the invasive investigations usually done to ascertain the cause of MLS.
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spelling pubmed-47314832016-02-03 Childhood allergic bronchopulmonary aspergillosis presenting as a middle lobe syndrome Shah, Ashok Gera, Kamal Panjabi, Chandramani Asia Pac Allergy Educational & Teaching Material Allergic bronchopulmonary aspergillosis (ABPA) is infrequently documented in children with asthma. Although collapse is not uncommon, middle lobe syndrome (MLS) as a presentation of ABPA is rather a rarity. A 9-year-old female child with asthma presented with increase in intensity of symptoms along with a right midzone patchy consolidation on a chest radiograph. In addition, an ill-defined opacity abutting the right cardiac border with loss of cardiac silhouette was noted. A right lateral view confirmed a MLS, which was further corroborated by high resolution computed tomography. Central bronchiectasis was also observed, which prompted a work-up for ABPA. The child met 7/8 major diagnostic criteria for ABPA. She was then initiated on oral prednisolone that resulted in a marked clinical improvement within a fortnight. Radiological clearance occurred at 3 months with inflation of the middle lobe. ABPA presenting with MLS in a child is yet to be reported. A high index of suspicion is required to establish the diagnosis of ABPA in a child presenting with MLS. This would obviate the invasive investigations usually done to ascertain the cause of MLS. Asia Pacific Association of Allergy, Asthma and Clinical Immunology 2016-01 2016-01-27 /pmc/articles/PMC4731483/ /pubmed/26844222 http://dx.doi.org/10.5415/apallergy.2016.6.1.67 Text en Copyright © 2016. Asia Pacific Association of Allergy, Asthma and Clinical Immunology. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Educational & Teaching Material
Shah, Ashok
Gera, Kamal
Panjabi, Chandramani
Childhood allergic bronchopulmonary aspergillosis presenting as a middle lobe syndrome
title Childhood allergic bronchopulmonary aspergillosis presenting as a middle lobe syndrome
title_full Childhood allergic bronchopulmonary aspergillosis presenting as a middle lobe syndrome
title_fullStr Childhood allergic bronchopulmonary aspergillosis presenting as a middle lobe syndrome
title_full_unstemmed Childhood allergic bronchopulmonary aspergillosis presenting as a middle lobe syndrome
title_short Childhood allergic bronchopulmonary aspergillosis presenting as a middle lobe syndrome
title_sort childhood allergic bronchopulmonary aspergillosis presenting as a middle lobe syndrome
topic Educational & Teaching Material
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731483/
https://www.ncbi.nlm.nih.gov/pubmed/26844222
http://dx.doi.org/10.5415/apallergy.2016.6.1.67
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