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Human Motor Cortex Functional Changes in Acute Stroke: Gender Effects

The acute phase of stroke is accompanied by functional changes in the activity and interplay of both hemispheres. In healthy subjects, gender is known to impact the functional brain organization. We investigated whether gender influences also acute stroke functional changes. In thirty-five ischemic...

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Autores principales: Di Lazzaro, Vincenzo, Pellegrino, Giovanni, Di Pino, Giovanni, Ranieri, Federico, Lotti, Fiorenza, Florio, Lucia, Capone, Fioravante
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731507/
https://www.ncbi.nlm.nih.gov/pubmed/26858590
http://dx.doi.org/10.3389/fnins.2016.00010
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author Di Lazzaro, Vincenzo
Pellegrino, Giovanni
Di Pino, Giovanni
Ranieri, Federico
Lotti, Fiorenza
Florio, Lucia
Capone, Fioravante
author_facet Di Lazzaro, Vincenzo
Pellegrino, Giovanni
Di Pino, Giovanni
Ranieri, Federico
Lotti, Fiorenza
Florio, Lucia
Capone, Fioravante
author_sort Di Lazzaro, Vincenzo
collection PubMed
description The acute phase of stroke is accompanied by functional changes in the activity and interplay of both hemispheres. In healthy subjects, gender is known to impact the functional brain organization. We investigated whether gender influences also acute stroke functional changes. In thirty-five ischemic stroke patients, we evaluated the excitability of the affected (AH) and unaffected hemisphere (UH) by measuring resting and active motor threshold (AMT) and motor-evoked potential amplitude under baseline conditions and after intermittent theta burst stimulation (iTBS) of AH. We also computed an index of the excitability balance between the hemispheres, laterality indexes (LI), to evidence hemispheric asymmetry. AMT differed significantly between AH and UH only in the male group (p = 0.004), not in females (p > 0.200), and both LI(AMT) and LI(RMT) were significantly higher in males than in females (respectively p = 0.033 and p = 0.042). LTP-like activity induced by iTBS in AH was more frequent in females. Gender influences the functional excitability changes that take place after human stroke and the level of LTP that can be induced by repetitive stimulation. This knowledge is of high value in the attempt of individualizing to different genders any non-invasive stimulation strategy designed to foster stroke recovery.
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spelling pubmed-47315072016-02-08 Human Motor Cortex Functional Changes in Acute Stroke: Gender Effects Di Lazzaro, Vincenzo Pellegrino, Giovanni Di Pino, Giovanni Ranieri, Federico Lotti, Fiorenza Florio, Lucia Capone, Fioravante Front Neurosci Psychiatry The acute phase of stroke is accompanied by functional changes in the activity and interplay of both hemispheres. In healthy subjects, gender is known to impact the functional brain organization. We investigated whether gender influences also acute stroke functional changes. In thirty-five ischemic stroke patients, we evaluated the excitability of the affected (AH) and unaffected hemisphere (UH) by measuring resting and active motor threshold (AMT) and motor-evoked potential amplitude under baseline conditions and after intermittent theta burst stimulation (iTBS) of AH. We also computed an index of the excitability balance between the hemispheres, laterality indexes (LI), to evidence hemispheric asymmetry. AMT differed significantly between AH and UH only in the male group (p = 0.004), not in females (p > 0.200), and both LI(AMT) and LI(RMT) were significantly higher in males than in females (respectively p = 0.033 and p = 0.042). LTP-like activity induced by iTBS in AH was more frequent in females. Gender influences the functional excitability changes that take place after human stroke and the level of LTP that can be induced by repetitive stimulation. This knowledge is of high value in the attempt of individualizing to different genders any non-invasive stimulation strategy designed to foster stroke recovery. Frontiers Media S.A. 2016-01-29 /pmc/articles/PMC4731507/ /pubmed/26858590 http://dx.doi.org/10.3389/fnins.2016.00010 Text en Copyright © 2016 Di Lazzaro, Pellegrino, Di Pino, Ranieri, Lotti, Florio and Capone. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Di Lazzaro, Vincenzo
Pellegrino, Giovanni
Di Pino, Giovanni
Ranieri, Federico
Lotti, Fiorenza
Florio, Lucia
Capone, Fioravante
Human Motor Cortex Functional Changes in Acute Stroke: Gender Effects
title Human Motor Cortex Functional Changes in Acute Stroke: Gender Effects
title_full Human Motor Cortex Functional Changes in Acute Stroke: Gender Effects
title_fullStr Human Motor Cortex Functional Changes in Acute Stroke: Gender Effects
title_full_unstemmed Human Motor Cortex Functional Changes in Acute Stroke: Gender Effects
title_short Human Motor Cortex Functional Changes in Acute Stroke: Gender Effects
title_sort human motor cortex functional changes in acute stroke: gender effects
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731507/
https://www.ncbi.nlm.nih.gov/pubmed/26858590
http://dx.doi.org/10.3389/fnins.2016.00010
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