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Effect of Premedication with Indomethacin and Ibuprofen on Postoperative Endodontic Pain: A Clinical Trial
INTRODUCTION: Post-endodontic pain is one of the main problems for both patients and dentists. The purpose of this study was to compare the effectiveness of premedication with indomethacin and ibuprofen for management of postoperative endodontic pain. METHODS AND MATERIALS: In this clinical trial, m...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Iranian Center for Endodontic Research
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731535/ https://www.ncbi.nlm.nih.gov/pubmed/26843879 http://dx.doi.org/10.7508/iej.2016.01.011 |
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author | Mokhtari, Fatemeh Yazdi, Kamal Mahabadi, Amir Mohammad Modaresi, Seyed Jalil Hamzeheil, Zeinab |
author_facet | Mokhtari, Fatemeh Yazdi, Kamal Mahabadi, Amir Mohammad Modaresi, Seyed Jalil Hamzeheil, Zeinab |
author_sort | Mokhtari, Fatemeh |
collection | PubMed |
description | INTRODUCTION: Post-endodontic pain is one of the main problems for both patients and dentists. The purpose of this study was to compare the effectiveness of premedication with indomethacin and ibuprofen for management of postoperative endodontic pain. METHODS AND MATERIALS: In this clinical trial, mandibular molars with irreversible pulpitis were endodontically treated in 66 patients. The medicines were prepared similarly in the form of capsules containing 400 mg ibuprofen (group A), 25 mg indomethacin (group B) and placebo (group C). The patients were given one capsule 1 h before the start of treatment. Patients recorded their pain measured by a visual analogue scale (VAS) at medication time, during treatment and 8, 12 and 24 h after treatment. The data were analyzed using the chi-square, repeated measures ANOVA, paired t-test, Tamhane and Pearson correlation coefficient. RESULTS: Ibuprofen and indomethacin significantly reduced the postoperative pain in comparison with placebo during treatment and 8 h after treatment; however, there were no significant differences between them 12 and 24 h after treatment. CONCLUSION: Premedication with ibuprofen and indomethacin can effectively control short term post-operative pain; the lower incidence of side effects and greater analgesic power of ibuprofen make it a superior choice. |
format | Online Article Text |
id | pubmed-4731535 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Iranian Center for Endodontic Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-47315352016-02-03 Effect of Premedication with Indomethacin and Ibuprofen on Postoperative Endodontic Pain: A Clinical Trial Mokhtari, Fatemeh Yazdi, Kamal Mahabadi, Amir Mohammad Modaresi, Seyed Jalil Hamzeheil, Zeinab Iran Endod J Original Article INTRODUCTION: Post-endodontic pain is one of the main problems for both patients and dentists. The purpose of this study was to compare the effectiveness of premedication with indomethacin and ibuprofen for management of postoperative endodontic pain. METHODS AND MATERIALS: In this clinical trial, mandibular molars with irreversible pulpitis were endodontically treated in 66 patients. The medicines were prepared similarly in the form of capsules containing 400 mg ibuprofen (group A), 25 mg indomethacin (group B) and placebo (group C). The patients were given one capsule 1 h before the start of treatment. Patients recorded their pain measured by a visual analogue scale (VAS) at medication time, during treatment and 8, 12 and 24 h after treatment. The data were analyzed using the chi-square, repeated measures ANOVA, paired t-test, Tamhane and Pearson correlation coefficient. RESULTS: Ibuprofen and indomethacin significantly reduced the postoperative pain in comparison with placebo during treatment and 8 h after treatment; however, there were no significant differences between them 12 and 24 h after treatment. CONCLUSION: Premedication with ibuprofen and indomethacin can effectively control short term post-operative pain; the lower incidence of side effects and greater analgesic power of ibuprofen make it a superior choice. Iranian Center for Endodontic Research 2016 2015-12-24 /pmc/articles/PMC4731535/ /pubmed/26843879 http://dx.doi.org/10.7508/iej.2016.01.011 Text en © 2016, Iranian Center for Endodontic Research This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Mokhtari, Fatemeh Yazdi, Kamal Mahabadi, Amir Mohammad Modaresi, Seyed Jalil Hamzeheil, Zeinab Effect of Premedication with Indomethacin and Ibuprofen on Postoperative Endodontic Pain: A Clinical Trial |
title | Effect of Premedication with Indomethacin and Ibuprofen on Postoperative Endodontic Pain: A Clinical Trial |
title_full | Effect of Premedication with Indomethacin and Ibuprofen on Postoperative Endodontic Pain: A Clinical Trial |
title_fullStr | Effect of Premedication with Indomethacin and Ibuprofen on Postoperative Endodontic Pain: A Clinical Trial |
title_full_unstemmed | Effect of Premedication with Indomethacin and Ibuprofen on Postoperative Endodontic Pain: A Clinical Trial |
title_short | Effect of Premedication with Indomethacin and Ibuprofen on Postoperative Endodontic Pain: A Clinical Trial |
title_sort | effect of premedication with indomethacin and ibuprofen on postoperative endodontic pain: a clinical trial |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731535/ https://www.ncbi.nlm.nih.gov/pubmed/26843879 http://dx.doi.org/10.7508/iej.2016.01.011 |
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