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The Influence of Genotype Polymorphism on Morphine Analgesic Effect for Postoperative Pain in Children

BACKGROUND: Although opioids are the most commonly used medications to control postoperative pain in children, the analgesic effects could have a large inter-individual variability according to genotypes. The aim of this study was to investigate the association between single nucleotide polymorphism...

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Autores principales: Lee, Mi Geum, Kim, Hyun Jung, Lee, Keun Hwa, Choi, Yun Suk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Pain Society 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731550/
https://www.ncbi.nlm.nih.gov/pubmed/26839669
http://dx.doi.org/10.3344/kjp.2016.29.1.34
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author Lee, Mi Geum
Kim, Hyun Jung
Lee, Keun Hwa
Choi, Yun Suk
author_facet Lee, Mi Geum
Kim, Hyun Jung
Lee, Keun Hwa
Choi, Yun Suk
author_sort Lee, Mi Geum
collection PubMed
description BACKGROUND: Although opioids are the most commonly used medications to control postoperative pain in children, the analgesic effects could have a large inter-individual variability according to genotypes. The aim of this study was to investigate the association between single nucleotide polymorphisms and the analgesic effect of morphine for postoperative pain in children. METHODS: A prospective study was conducted in 88 healthy children undergoing tonsillectomy, who received morphine during the operation. The postoperative pain score, frequency of rescue analgesics, and side effects of morphine were assessed in the post-anesthesia care unit. The children were genotyped for OPRM1 A118G, ABCB1 C3435T, and COMT Val158Met. RESULTS: Children with at least one G allele for OPRM1 (AG/GG) had higher postoperative pain scores compared with those with the AA genotype at the time of discharge from the post-anesthesia care unit (P = 0.025). Other recovery profiles were not significantly different between the two groups. There was no significant relationship between genotypes and postoperative pain scores in analysis of ABCB1 and COMT polymorphisms. CONCLUSIONS: Genetic polymorphism at OPRM1 A118G, but not at ABCB1 C3435T and COMT Val158Met, influences the analgesic effect of morphine for immediate acute postoperative pain in children.
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spelling pubmed-47315502016-02-02 The Influence of Genotype Polymorphism on Morphine Analgesic Effect for Postoperative Pain in Children Lee, Mi Geum Kim, Hyun Jung Lee, Keun Hwa Choi, Yun Suk Korean J Pain Original Article BACKGROUND: Although opioids are the most commonly used medications to control postoperative pain in children, the analgesic effects could have a large inter-individual variability according to genotypes. The aim of this study was to investigate the association between single nucleotide polymorphisms and the analgesic effect of morphine for postoperative pain in children. METHODS: A prospective study was conducted in 88 healthy children undergoing tonsillectomy, who received morphine during the operation. The postoperative pain score, frequency of rescue analgesics, and side effects of morphine were assessed in the post-anesthesia care unit. The children were genotyped for OPRM1 A118G, ABCB1 C3435T, and COMT Val158Met. RESULTS: Children with at least one G allele for OPRM1 (AG/GG) had higher postoperative pain scores compared with those with the AA genotype at the time of discharge from the post-anesthesia care unit (P = 0.025). Other recovery profiles were not significantly different between the two groups. There was no significant relationship between genotypes and postoperative pain scores in analysis of ABCB1 and COMT polymorphisms. CONCLUSIONS: Genetic polymorphism at OPRM1 A118G, but not at ABCB1 C3435T and COMT Val158Met, influences the analgesic effect of morphine for immediate acute postoperative pain in children. The Korean Pain Society 2016-01 2016-01-04 /pmc/articles/PMC4731550/ /pubmed/26839669 http://dx.doi.org/10.3344/kjp.2016.29.1.34 Text en Copyright © The Korean Pain Society, 2016 http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Lee, Mi Geum
Kim, Hyun Jung
Lee, Keun Hwa
Choi, Yun Suk
The Influence of Genotype Polymorphism on Morphine Analgesic Effect for Postoperative Pain in Children
title The Influence of Genotype Polymorphism on Morphine Analgesic Effect for Postoperative Pain in Children
title_full The Influence of Genotype Polymorphism on Morphine Analgesic Effect for Postoperative Pain in Children
title_fullStr The Influence of Genotype Polymorphism on Morphine Analgesic Effect for Postoperative Pain in Children
title_full_unstemmed The Influence of Genotype Polymorphism on Morphine Analgesic Effect for Postoperative Pain in Children
title_short The Influence of Genotype Polymorphism on Morphine Analgesic Effect for Postoperative Pain in Children
title_sort influence of genotype polymorphism on morphine analgesic effect for postoperative pain in children
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731550/
https://www.ncbi.nlm.nih.gov/pubmed/26839669
http://dx.doi.org/10.3344/kjp.2016.29.1.34
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