On the Utility of Short Echo Time (TE) Single Voxel 1H–MRS in Non–Invasive Detection of 2–Hydroxyglutarate (2HG); Challenges and Potential Improvement Illustrated with Animal Models Using MRUI and LCModel

Mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) are frequently found in brain tumors, and the resulting onco–metabolite, 2–hydroxyglutarate (2HG), has been suggested to be a potential diagnostic and prognostic biomarker of the diseases. Indeed, recent studies have demonstrated the feasibility...

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Detalles Bibliográficos
Autores principales: Heo, Hwon, Kim, Sungjin, Lee, Hyeong Hun, Cho, Hye Rim, Xu, Wen Jun, Lee, Se-Hoon, Park, Chul-Kee, Park, Sunghyouk, Choi, Seung Hong, Kim, Hyeonjin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731570/
https://www.ncbi.nlm.nih.gov/pubmed/26820720
http://dx.doi.org/10.1371/journal.pone.0147794

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