Accumulation of 3-hydroxytetradecenoic acid: Cause or corollary of glucolipotoxic impairment of pancreatic β-cell bioenergetics?

OBJECTIVES: Hyperglycemia and elevated blood lipids are the presumed precipitating causes of β-cell damage in T2DM as the result of a process termed “glucolipotoxicity”. Here, we tested whether glucolipotoxic pathophysiology is caused by defective bioenergetics using islets in culture. METHODS: Insu...

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Detalles Bibliográficos
Autores principales: Doliba, Nicolai M., Liu, Qing, Li, Changhong, Chen, Jie, Chen, Pan, Liu, Chengyang, Frederick, David W., Baur, Joseph A., Bennett, Michael J., Naji, Ali, Matschinsky, Franz M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731732/
https://www.ncbi.nlm.nih.gov/pubmed/26909309
http://dx.doi.org/10.1016/j.molmet.2015.09.010

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