Bioenergetic cues shift FXR splicing towards FXRα2 to modulate hepatic lipolysis and fatty acid metabolism

OBJECTIVE: Farnesoid X receptor (FXR) plays a prominent role in hepatic lipid metabolism. The FXR gene encodes four proteins with structural differences suggestive of discrete biological functions about which little is known. METHODS: We expressed each FXR variant in primary hepatocytes and evaluate...

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Detalles Bibliográficos
Autores principales: Correia, Jorge C., Massart, Julie, de Boer, Jan Freark, Porsmyr-Palmertz, Margareta, Martínez-Redondo, Vicente, Agudelo, Leandro Z., Sinha, Indranil, Meierhofer, David, Ribeiro, Vera, Björnholm, Marie, Sauer, Sascha, Dahlman-Wright, Karin, Zierath, Juleen R., Groen, Albert K., Ruas, Jorge L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731735/
https://www.ncbi.nlm.nih.gov/pubmed/26909306
http://dx.doi.org/10.1016/j.molmet.2015.09.005

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