Naturally occurring proteinaceous nanoparticles in Coptidis Rhizoma extract act as concentration-dependent carriers that facilitate berberine absorption

Pharmacological activities of some natural products diminish and even disappear after purification. In this study, we explored the mechanisms underlying the decrease of acute oral toxicity of Coptidis Rhizoma extract after purification. The water solubility, in vitro absorption, and plasma exposure...

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Detalles Bibliográficos
Autores principales: Ma, Bing-Liang, Yin, Chun, Zhang, Bo-Kai, Dai, Yan, Jia, Yi-Qun, Yang, Yan, Li, Qiao, Shi, Rong, Wang, Tian-Ming, Wu, Jia-Sheng, Li, Yuan-Yuan, Lin, Ge, Ma, Yue-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731763/
https://www.ncbi.nlm.nih.gov/pubmed/26822920
http://dx.doi.org/10.1038/srep20110

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