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The relationship between oxidised LDL, endothelial progenitor cells and coronary endothelial function in patients with CHD

OBJECTIVE: The balance between coronary endothelial dysfunction and repair is influenced by many protective and deleterious factors circulating in the blood. We studied the relationship between oxidised low-density lipoprotein (oxLDL), circulating endothelial progenitor cells (EPCs) and coronary end...

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Autores principales: Watt, Jonathan, Kennedy, Simon, Ahmed, Nadeem, Hayhurst, James, McClure, John D, Berry, Colin, Wadsworth, Roger M, Oldroyd, Keith G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731840/
https://www.ncbi.nlm.nih.gov/pubmed/26848395
http://dx.doi.org/10.1136/openhrt-2015-000342
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author Watt, Jonathan
Kennedy, Simon
Ahmed, Nadeem
Hayhurst, James
McClure, John D
Berry, Colin
Wadsworth, Roger M
Oldroyd, Keith G
author_facet Watt, Jonathan
Kennedy, Simon
Ahmed, Nadeem
Hayhurst, James
McClure, John D
Berry, Colin
Wadsworth, Roger M
Oldroyd, Keith G
author_sort Watt, Jonathan
collection PubMed
description OBJECTIVE: The balance between coronary endothelial dysfunction and repair is influenced by many protective and deleterious factors circulating in the blood. We studied the relationship between oxidised low-density lipoprotein (oxLDL), circulating endothelial progenitor cells (EPCs) and coronary endothelial function in patients with stable coronary heart disease (CHD). METHODS: 33 patients with stable CHD were studied. Plasma oxLDL was measured using ELISA, coronary endothelial function was assessed using intracoronary acetylcholine infusion and EPCs were quantified using flow cytometry for CD34(+)/KDR(+) cells. RESULTS: Plasma oxLDL correlated positively with the number of EPCs in the blood (r=0.46, p=0.02). There was a positive correlation between the number of circulating EPCs and coronary endothelial function (r=0.42, p=0.04). There was no significant correlation between oxLDL and coronary endothelial function. CONCLUSIONS: Plasma levels of oxLDL are associated with increased circulating EPCs in the blood of patients with CHD, which may reflect a host-repair response to endothelial injury. Patients with stable CHD had a high prevalence of coronary endothelial dysfunction, which was associated with lower numbers of circulating EPCs, suggesting a mechanistic link between endothelial dysfunction and the pathogenesis of atherosclerosis.
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spelling pubmed-47318402016-02-04 The relationship between oxidised LDL, endothelial progenitor cells and coronary endothelial function in patients with CHD Watt, Jonathan Kennedy, Simon Ahmed, Nadeem Hayhurst, James McClure, John D Berry, Colin Wadsworth, Roger M Oldroyd, Keith G Open Heart Interventional Cardiology OBJECTIVE: The balance between coronary endothelial dysfunction and repair is influenced by many protective and deleterious factors circulating in the blood. We studied the relationship between oxidised low-density lipoprotein (oxLDL), circulating endothelial progenitor cells (EPCs) and coronary endothelial function in patients with stable coronary heart disease (CHD). METHODS: 33 patients with stable CHD were studied. Plasma oxLDL was measured using ELISA, coronary endothelial function was assessed using intracoronary acetylcholine infusion and EPCs were quantified using flow cytometry for CD34(+)/KDR(+) cells. RESULTS: Plasma oxLDL correlated positively with the number of EPCs in the blood (r=0.46, p=0.02). There was a positive correlation between the number of circulating EPCs and coronary endothelial function (r=0.42, p=0.04). There was no significant correlation between oxLDL and coronary endothelial function. CONCLUSIONS: Plasma levels of oxLDL are associated with increased circulating EPCs in the blood of patients with CHD, which may reflect a host-repair response to endothelial injury. Patients with stable CHD had a high prevalence of coronary endothelial dysfunction, which was associated with lower numbers of circulating EPCs, suggesting a mechanistic link between endothelial dysfunction and the pathogenesis of atherosclerosis. BMJ Publishing Group 2016-01-28 /pmc/articles/PMC4731840/ /pubmed/26848395 http://dx.doi.org/10.1136/openhrt-2015-000342 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/
spellingShingle Interventional Cardiology
Watt, Jonathan
Kennedy, Simon
Ahmed, Nadeem
Hayhurst, James
McClure, John D
Berry, Colin
Wadsworth, Roger M
Oldroyd, Keith G
The relationship between oxidised LDL, endothelial progenitor cells and coronary endothelial function in patients with CHD
title The relationship between oxidised LDL, endothelial progenitor cells and coronary endothelial function in patients with CHD
title_full The relationship between oxidised LDL, endothelial progenitor cells and coronary endothelial function in patients with CHD
title_fullStr The relationship between oxidised LDL, endothelial progenitor cells and coronary endothelial function in patients with CHD
title_full_unstemmed The relationship between oxidised LDL, endothelial progenitor cells and coronary endothelial function in patients with CHD
title_short The relationship between oxidised LDL, endothelial progenitor cells and coronary endothelial function in patients with CHD
title_sort relationship between oxidised ldl, endothelial progenitor cells and coronary endothelial function in patients with chd
topic Interventional Cardiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731840/
https://www.ncbi.nlm.nih.gov/pubmed/26848395
http://dx.doi.org/10.1136/openhrt-2015-000342
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