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The relationship between oxidised LDL, endothelial progenitor cells and coronary endothelial function in patients with CHD
OBJECTIVE: The balance between coronary endothelial dysfunction and repair is influenced by many protective and deleterious factors circulating in the blood. We studied the relationship between oxidised low-density lipoprotein (oxLDL), circulating endothelial progenitor cells (EPCs) and coronary end...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731840/ https://www.ncbi.nlm.nih.gov/pubmed/26848395 http://dx.doi.org/10.1136/openhrt-2015-000342 |
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author | Watt, Jonathan Kennedy, Simon Ahmed, Nadeem Hayhurst, James McClure, John D Berry, Colin Wadsworth, Roger M Oldroyd, Keith G |
author_facet | Watt, Jonathan Kennedy, Simon Ahmed, Nadeem Hayhurst, James McClure, John D Berry, Colin Wadsworth, Roger M Oldroyd, Keith G |
author_sort | Watt, Jonathan |
collection | PubMed |
description | OBJECTIVE: The balance between coronary endothelial dysfunction and repair is influenced by many protective and deleterious factors circulating in the blood. We studied the relationship between oxidised low-density lipoprotein (oxLDL), circulating endothelial progenitor cells (EPCs) and coronary endothelial function in patients with stable coronary heart disease (CHD). METHODS: 33 patients with stable CHD were studied. Plasma oxLDL was measured using ELISA, coronary endothelial function was assessed using intracoronary acetylcholine infusion and EPCs were quantified using flow cytometry for CD34(+)/KDR(+) cells. RESULTS: Plasma oxLDL correlated positively with the number of EPCs in the blood (r=0.46, p=0.02). There was a positive correlation between the number of circulating EPCs and coronary endothelial function (r=0.42, p=0.04). There was no significant correlation between oxLDL and coronary endothelial function. CONCLUSIONS: Plasma levels of oxLDL are associated with increased circulating EPCs in the blood of patients with CHD, which may reflect a host-repair response to endothelial injury. Patients with stable CHD had a high prevalence of coronary endothelial dysfunction, which was associated with lower numbers of circulating EPCs, suggesting a mechanistic link between endothelial dysfunction and the pathogenesis of atherosclerosis. |
format | Online Article Text |
id | pubmed-4731840 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-47318402016-02-04 The relationship between oxidised LDL, endothelial progenitor cells and coronary endothelial function in patients with CHD Watt, Jonathan Kennedy, Simon Ahmed, Nadeem Hayhurst, James McClure, John D Berry, Colin Wadsworth, Roger M Oldroyd, Keith G Open Heart Interventional Cardiology OBJECTIVE: The balance between coronary endothelial dysfunction and repair is influenced by many protective and deleterious factors circulating in the blood. We studied the relationship between oxidised low-density lipoprotein (oxLDL), circulating endothelial progenitor cells (EPCs) and coronary endothelial function in patients with stable coronary heart disease (CHD). METHODS: 33 patients with stable CHD were studied. Plasma oxLDL was measured using ELISA, coronary endothelial function was assessed using intracoronary acetylcholine infusion and EPCs were quantified using flow cytometry for CD34(+)/KDR(+) cells. RESULTS: Plasma oxLDL correlated positively with the number of EPCs in the blood (r=0.46, p=0.02). There was a positive correlation between the number of circulating EPCs and coronary endothelial function (r=0.42, p=0.04). There was no significant correlation between oxLDL and coronary endothelial function. CONCLUSIONS: Plasma levels of oxLDL are associated with increased circulating EPCs in the blood of patients with CHD, which may reflect a host-repair response to endothelial injury. Patients with stable CHD had a high prevalence of coronary endothelial dysfunction, which was associated with lower numbers of circulating EPCs, suggesting a mechanistic link between endothelial dysfunction and the pathogenesis of atherosclerosis. BMJ Publishing Group 2016-01-28 /pmc/articles/PMC4731840/ /pubmed/26848395 http://dx.doi.org/10.1136/openhrt-2015-000342 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Interventional Cardiology Watt, Jonathan Kennedy, Simon Ahmed, Nadeem Hayhurst, James McClure, John D Berry, Colin Wadsworth, Roger M Oldroyd, Keith G The relationship between oxidised LDL, endothelial progenitor cells and coronary endothelial function in patients with CHD |
title | The relationship between oxidised LDL, endothelial progenitor cells and coronary endothelial function in patients with CHD |
title_full | The relationship between oxidised LDL, endothelial progenitor cells and coronary endothelial function in patients with CHD |
title_fullStr | The relationship between oxidised LDL, endothelial progenitor cells and coronary endothelial function in patients with CHD |
title_full_unstemmed | The relationship between oxidised LDL, endothelial progenitor cells and coronary endothelial function in patients with CHD |
title_short | The relationship between oxidised LDL, endothelial progenitor cells and coronary endothelial function in patients with CHD |
title_sort | relationship between oxidised ldl, endothelial progenitor cells and coronary endothelial function in patients with chd |
topic | Interventional Cardiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731840/ https://www.ncbi.nlm.nih.gov/pubmed/26848395 http://dx.doi.org/10.1136/openhrt-2015-000342 |
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