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Development of a transgenic mouse model of hepatocellular carcinoma with a liver fibrosis background
BACKGROUND: Liver fibrosis and its end-stage disease, cirrhosis, are major risk factors for hepatocellular carcinoma (HCC) and present in 80 to 90 % of patients with HCC. Current genetically engineered mouse models for HCC, however, generally do not feature liver fibrosis, which is a critical discre...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731926/ https://www.ncbi.nlm.nih.gov/pubmed/26821924 http://dx.doi.org/10.1186/s12876-016-0423-6 |