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Beclin1 and HMGB1 ameliorate the α-synuclein-mediated autophagy inhibition in PC12 cells

BACKGROUND: Aberrant α-synuclein aggregation due to the deficiency of ubiquitin-proteasome or of autophagy characterizes the parkinson disease (PD). High mobility group box 1 (HMGB1) is a novel stress sensor to mediate the persistent neuro-inflammation and the consequent progressive neurodegeneratio...

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Detalles Bibliográficos
Autores principales:	Wang, Kaihua, Huang, Jianmin, Xie, Wei, Huang, Longjian, Zhong, Canhua, Chen, Zhenzhen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731928/ https://www.ncbi.nlm.nih.gov/pubmed/26822891 http://dx.doi.org/10.1186/s13000-016-0459-5

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