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Effect of short-term weight loss on mental stress-induced cardiovascular and pro-inflammatory responses in women
Epidemiologic evidence links psychosocial stress with obesity but experimental studies examining the mechanisms that mediates the effect of stress on adiposity are scarce. The aim of this study was to investigate whether changes in adiposity following minimal weight loss affect heightened stress res...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Informa Healthcare
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4732430/ https://www.ncbi.nlm.nih.gov/pubmed/26181102 http://dx.doi.org/10.3109/10253890.2015.1064889 |
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author | Endrighi, Romano Hamer, Mark Hackett, Ruth A. Carvalho, Livia A. Jackson, Sarah E. Wardle, Jane Steptoe, Andrew |
author_facet | Endrighi, Romano Hamer, Mark Hackett, Ruth A. Carvalho, Livia A. Jackson, Sarah E. Wardle, Jane Steptoe, Andrew |
author_sort | Endrighi, Romano |
collection | PubMed |
description | Epidemiologic evidence links psychosocial stress with obesity but experimental studies examining the mechanisms that mediates the effect of stress on adiposity are scarce. The aim of this study was to investigate whether changes in adiposity following minimal weight loss affect heightened stress responses in women, and examine the role of the adipokine leptin in driving inflammatory responses. Twenty-three overweight or obese, but otherwise healthy, women (M age = 30.41 ± 8.0 years; BMI = 31.9 ± 4.1 kg/m(2)) completed standardized acute mental stress before and after a 9-week calorie restriction program designed to modify adiposity levels. Cardiovascular (blood pressure and heart rate) and inflammatory cytokines (leptin and interleukin-6; IL-6) responses to mental stress were assessed several times between baseline and a 45-min post-stress recovery period. There were modest changes in adiposity measures while the adipokine leptin was markedly reduced (−27%) after the intervention. Blood pressure reactivity was attenuated (−3.38 ± 1.39 mmHg) and heart rate recovery was improved (2.07 ± 0.96 Bpm) after weight loss. Blood pressure responses were inversely associated with changes in waist to hip ratio post intervention. Decreased levels of circulating leptin following weight loss were inversely associated with the IL-6 inflammatory response to stress (r = −0.47). We offered preliminary evidence suggesting that modest changes in adiposity following a brief caloric restriction program may yield beneficial effect on cardiovascular stress responses. In addition, reductions in basal leptin activity might be important in blunting pro-inflammatory responses. Large randomized trials of the effect of adiposity on autonomic responses are thus warranted. |
format | Online Article Text |
id | pubmed-4732430 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Informa Healthcare |
record_format | MEDLINE/PubMed |
spelling | pubmed-47324302016-02-16 Effect of short-term weight loss on mental stress-induced cardiovascular and pro-inflammatory responses in women Endrighi, Romano Hamer, Mark Hackett, Ruth A. Carvalho, Livia A. Jackson, Sarah E. Wardle, Jane Steptoe, Andrew Stress Short Communication Epidemiologic evidence links psychosocial stress with obesity but experimental studies examining the mechanisms that mediates the effect of stress on adiposity are scarce. The aim of this study was to investigate whether changes in adiposity following minimal weight loss affect heightened stress responses in women, and examine the role of the adipokine leptin in driving inflammatory responses. Twenty-three overweight or obese, but otherwise healthy, women (M age = 30.41 ± 8.0 years; BMI = 31.9 ± 4.1 kg/m(2)) completed standardized acute mental stress before and after a 9-week calorie restriction program designed to modify adiposity levels. Cardiovascular (blood pressure and heart rate) and inflammatory cytokines (leptin and interleukin-6; IL-6) responses to mental stress were assessed several times between baseline and a 45-min post-stress recovery period. There were modest changes in adiposity measures while the adipokine leptin was markedly reduced (−27%) after the intervention. Blood pressure reactivity was attenuated (−3.38 ± 1.39 mmHg) and heart rate recovery was improved (2.07 ± 0.96 Bpm) after weight loss. Blood pressure responses were inversely associated with changes in waist to hip ratio post intervention. Decreased levels of circulating leptin following weight loss were inversely associated with the IL-6 inflammatory response to stress (r = −0.47). We offered preliminary evidence suggesting that modest changes in adiposity following a brief caloric restriction program may yield beneficial effect on cardiovascular stress responses. In addition, reductions in basal leptin activity might be important in blunting pro-inflammatory responses. Large randomized trials of the effect of adiposity on autonomic responses are thus warranted. Informa Healthcare 2015-09-03 2015-07-16 /pmc/articles/PMC4732430/ /pubmed/26181102 http://dx.doi.org/10.3109/10253890.2015.1064889 Text en © 2015 The Author(s). Published by Taylor and Francis. http://creativecommons.org/Licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/Licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Communication Endrighi, Romano Hamer, Mark Hackett, Ruth A. Carvalho, Livia A. Jackson, Sarah E. Wardle, Jane Steptoe, Andrew Effect of short-term weight loss on mental stress-induced cardiovascular and pro-inflammatory responses in women |
title | Effect of short-term weight loss on mental stress-induced cardiovascular and pro-inflammatory responses in women |
title_full | Effect of short-term weight loss on mental stress-induced cardiovascular and pro-inflammatory responses in women |
title_fullStr | Effect of short-term weight loss on mental stress-induced cardiovascular and pro-inflammatory responses in women |
title_full_unstemmed | Effect of short-term weight loss on mental stress-induced cardiovascular and pro-inflammatory responses in women |
title_short | Effect of short-term weight loss on mental stress-induced cardiovascular and pro-inflammatory responses in women |
title_sort | effect of short-term weight loss on mental stress-induced cardiovascular and pro-inflammatory responses in women |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4732430/ https://www.ncbi.nlm.nih.gov/pubmed/26181102 http://dx.doi.org/10.3109/10253890.2015.1064889 |
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