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Morning stiffness response with delayed-release prednisone after ineffective course of immediate-release prednisone
Objective: To assess morning stiffness in rheumatoid arthritis (RA) patients switched from immediate-release (IR) to delayed-release (DR) prednisone. Method: Circadian Administration of Prednisone in Rheumatoid Arthritis-1 (CAPRA-1) is a 12-week, randomized, multicentre, active-controlled study of m...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Informa Healthcare
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4732433/ https://www.ncbi.nlm.nih.gov/pubmed/26114379 http://dx.doi.org/10.3109/03009742.2015.1038582 |
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author | Alten, R Holt, R Grahn, A Rice, P Kent, J Buttgereit, F Gibofsky, A |
author_facet | Alten, R Holt, R Grahn, A Rice, P Kent, J Buttgereit, F Gibofsky, A |
author_sort | Alten, R |
collection | PubMed |
description | Objective: To assess morning stiffness in rheumatoid arthritis (RA) patients switched from immediate-release (IR) to delayed-release (DR) prednisone. Method: Circadian Administration of Prednisone in Rheumatoid Arthritis-1 (CAPRA-1) is a 12-week, randomized, multicentre, active-controlled study of morning stiffness that consisted of a double-blind phase and a 9-month open-label extension. Patients receiving IR prednisone with no significant improvement after the double-blind study were switched to DR prednisone. Morning stiffness duration and median absolute and relative changes in pain and global assessment were evaluated (3, 6, and 9 months). Results: In patients switched from IR to DR prednisone (n = 110), statistically significant reductions in morning stiffness occurred over 3 months and were sustained for 9 months. Absolute reduction of morning stiffness was ~50 min with > 40% relative reduction at each visit. Interleukin (IL)-6 levels were reduced by the same amount. Statistically significant and clinically meaningful mean reductions in morning stiffness were maintained at > 67 min at each visit along with significant improvements in pain and patient global assessment. There was no evidence of tachyphylaxis seen over the 9-month study. Conclusions: Patients receiving disease-modifying anti-rheumatic drugs (DMARDs) and IR prednisone who had not had significant reductions in morning stiffness demonstrated statistically significant and clinically meaningful improvements when switched to DR prednisone. |
format | Online Article Text |
id | pubmed-4732433 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Informa Healthcare |
record_format | MEDLINE/PubMed |
spelling | pubmed-47324332016-02-16 Morning stiffness response with delayed-release prednisone after ineffective course of immediate-release prednisone Alten, R Holt, R Grahn, A Rice, P Kent, J Buttgereit, F Gibofsky, A Scand J Rheumatol Short Communication Objective: To assess morning stiffness in rheumatoid arthritis (RA) patients switched from immediate-release (IR) to delayed-release (DR) prednisone. Method: Circadian Administration of Prednisone in Rheumatoid Arthritis-1 (CAPRA-1) is a 12-week, randomized, multicentre, active-controlled study of morning stiffness that consisted of a double-blind phase and a 9-month open-label extension. Patients receiving IR prednisone with no significant improvement after the double-blind study were switched to DR prednisone. Morning stiffness duration and median absolute and relative changes in pain and global assessment were evaluated (3, 6, and 9 months). Results: In patients switched from IR to DR prednisone (n = 110), statistically significant reductions in morning stiffness occurred over 3 months and were sustained for 9 months. Absolute reduction of morning stiffness was ~50 min with > 40% relative reduction at each visit. Interleukin (IL)-6 levels were reduced by the same amount. Statistically significant and clinically meaningful mean reductions in morning stiffness were maintained at > 67 min at each visit along with significant improvements in pain and patient global assessment. There was no evidence of tachyphylaxis seen over the 9-month study. Conclusions: Patients receiving disease-modifying anti-rheumatic drugs (DMARDs) and IR prednisone who had not had significant reductions in morning stiffness demonstrated statistically significant and clinically meaningful improvements when switched to DR prednisone. Informa Healthcare 2015-09-03 2015-06-26 /pmc/articles/PMC4732433/ /pubmed/26114379 http://dx.doi.org/10.3109/03009742.2015.1038582 Text en © 2015 Informa healthcare on license from Scandinavian Rheumatology Research Foundation http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. |
spellingShingle | Short Communication Alten, R Holt, R Grahn, A Rice, P Kent, J Buttgereit, F Gibofsky, A Morning stiffness response with delayed-release prednisone after ineffective course of immediate-release prednisone |
title | Morning stiffness response with delayed-release prednisone after ineffective course of immediate-release prednisone |
title_full | Morning stiffness response with delayed-release prednisone after ineffective course of immediate-release prednisone |
title_fullStr | Morning stiffness response with delayed-release prednisone after ineffective course of immediate-release prednisone |
title_full_unstemmed | Morning stiffness response with delayed-release prednisone after ineffective course of immediate-release prednisone |
title_short | Morning stiffness response with delayed-release prednisone after ineffective course of immediate-release prednisone |
title_sort | morning stiffness response with delayed-release prednisone after ineffective course of immediate-release prednisone |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4732433/ https://www.ncbi.nlm.nih.gov/pubmed/26114379 http://dx.doi.org/10.3109/03009742.2015.1038582 |
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