Sorafenib induces paradoxical phosphorylation of the extracellular signal-regulated kinase pathway in acute myeloid leukemia cells lacking FLT3-ITD mutation

Gain-of-function mutations in the RAS and FLT3 genes are frequently found in cells of acute myeloid leukemia (AML), leading to constitutive activation of signaling pathways that regulate fundamental cellular processes, and are therefore attractive targets for AML therapy. The multi-targeted kinase i...

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Detalles Bibliográficos
Autores principales: Fouladi, Fariba, Jehn, Lutz B., Metzelder, Stephan K., Hub, Florian, Henkenius, Katharina, Burchert, Andreas, Brendel, Cornelia, Stiewe, Thorsten, Neubauer, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Original Articles: Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4732463/
https://www.ncbi.nlm.nih.gov/pubmed/25665465
http://dx.doi.org/10.3109/10428194.2014.1003055

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