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Preeclampsia prevention: a case-control study nested in a cohort
BACKGROUND: Preeclampsia is the main complication of pregnancy in developing countries. Calcium starting at 14 weeks of pregnancy is indicated to prevent the disease. Recent advances in prevention of preeclampsia endorse the addition of conjugated linoleic acid. OBJECTIVE: To estimate the protective...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Universidad del Valle
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4732504/ https://www.ncbi.nlm.nih.gov/pubmed/26848195 |
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author | Alzate, Alberto Herrera-Medina, Rodolfo Pineda, Lucia M |
author_facet | Alzate, Alberto Herrera-Medina, Rodolfo Pineda, Lucia M |
author_sort | Alzate, Alberto |
collection | PubMed |
description | BACKGROUND: Preeclampsia is the main complication of pregnancy in developing countries. Calcium starting at 14 weeks of pregnancy is indicated to prevent the disease. Recent advances in prevention of preeclampsia endorse the addition of conjugated linoleic acid. OBJECTIVE: To estimate the protective effect from calcium alone, compared to calcium plus conjugated linoleic acid in nulliparous women at risk of preeclampsia. METHODS: A case-control design nested in the cohort of nulliparous women attending antenatal care from 2010 to 2014. The clinical histories of 387 cases of preeclampsia were compared with 1,054 normotensive controls. The exposure was prescriptions for calcium alone, the first period, or calcium plus conjugated linoleic acid, the second period, from 12 to 16 weeks of gestational age to labor. Confounding variables were controlled, allowing only nulliparous women into the study and stratifying by age, education and ethnic group. RESULTS: The average age was 26.4 yrs old (range= 13-45), 85% from mixed ethnic backgrounds and with high school education. There were no differences between women who received calcium carbonate and those who did not (OR= 0.96; 95% CI= 0.73-1.27). The group of adolescents (13 to 18 years old) in the calcium plus conjugated linoleic acid was protected for preeclampsia (OR= 0.00; 95% CI= 0.00-0.44) independent of the confounder variables. CONCLUSIONS: 1. Calcium supplementation during pregnancy did not have preventive effects on preeclampsia. 2. Calcium plus Conjugated Linoleic acid provided to adolescents was observed to have preventive effect on Preeclampsia. |
format | Online Article Text |
id | pubmed-4732504 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Universidad del Valle |
record_format | MEDLINE/PubMed |
spelling | pubmed-47325042016-02-04 Preeclampsia prevention: a case-control study nested in a cohort Alzate, Alberto Herrera-Medina, Rodolfo Pineda, Lucia M Colomb Med (Cali) Original Article BACKGROUND: Preeclampsia is the main complication of pregnancy in developing countries. Calcium starting at 14 weeks of pregnancy is indicated to prevent the disease. Recent advances in prevention of preeclampsia endorse the addition of conjugated linoleic acid. OBJECTIVE: To estimate the protective effect from calcium alone, compared to calcium plus conjugated linoleic acid in nulliparous women at risk of preeclampsia. METHODS: A case-control design nested in the cohort of nulliparous women attending antenatal care from 2010 to 2014. The clinical histories of 387 cases of preeclampsia were compared with 1,054 normotensive controls. The exposure was prescriptions for calcium alone, the first period, or calcium plus conjugated linoleic acid, the second period, from 12 to 16 weeks of gestational age to labor. Confounding variables were controlled, allowing only nulliparous women into the study and stratifying by age, education and ethnic group. RESULTS: The average age was 26.4 yrs old (range= 13-45), 85% from mixed ethnic backgrounds and with high school education. There were no differences between women who received calcium carbonate and those who did not (OR= 0.96; 95% CI= 0.73-1.27). The group of adolescents (13 to 18 years old) in the calcium plus conjugated linoleic acid was protected for preeclampsia (OR= 0.00; 95% CI= 0.00-0.44) independent of the confounder variables. CONCLUSIONS: 1. Calcium supplementation during pregnancy did not have preventive effects on preeclampsia. 2. Calcium plus Conjugated Linoleic acid provided to adolescents was observed to have preventive effect on Preeclampsia. Universidad del Valle 2015-12-30 /pmc/articles/PMC4732504/ /pubmed/26848195 Text en http://creativecommons.org/licenses/by/3.0/ © 2015. Universidad del Valle. This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited |
spellingShingle | Original Article Alzate, Alberto Herrera-Medina, Rodolfo Pineda, Lucia M Preeclampsia prevention: a case-control study nested in a cohort |
title | Preeclampsia prevention: a case-control study nested in a cohort |
title_full | Preeclampsia prevention: a case-control study nested in a cohort |
title_fullStr | Preeclampsia prevention: a case-control study nested in a cohort |
title_full_unstemmed | Preeclampsia prevention: a case-control study nested in a cohort |
title_short | Preeclampsia prevention: a case-control study nested in a cohort |
title_sort | preeclampsia prevention: a case-control study nested in a cohort |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4732504/ https://www.ncbi.nlm.nih.gov/pubmed/26848195 |
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