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Region-Specific Defects of Respiratory Capacities in the Ndufs4(KO) Mouse Brain
BACKGROUND: Lack of NDUFS4, a subunit of mitochondrial complex I (NADH:ubiquinone oxidoreductase), causes Leigh syndrome (LS), a progressive encephalomyopathy. Knocking out Ndufs4, either systemically or in brain only, elicits LS in mice. In patients as well as in KO mice distinct regions of the bra...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4732614/ https://www.ncbi.nlm.nih.gov/pubmed/26824698 http://dx.doi.org/10.1371/journal.pone.0148219 |