Xp11 Translocation Renal Cell Carcinoma: Unusual Variant Masquerading as Upper Tract Urothelial Cell Carcinoma

Xp11 translocation renal cell carcinoma (TRCC) is a rare subtype of renal cell carcinoma characterized by chromosomal translocations involving the TFE3 gene located at the Xp11.2 locus. Initial cases were more common in children, but cases in older adults have begun to accrue and suggest a relativel...

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Detalles Bibliográficos
Autores principales: Akhavein, Arash, Han, Julia, Carter, Christopher, Al-Quran, Samer Z., Su, Li-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4733007/
https://www.ncbi.nlm.nih.gov/pubmed/26955551
http://dx.doi.org/10.1016/j.eucr.2014.02.003
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author Akhavein, Arash
Han, Julia
Carter, Christopher
Al-Quran, Samer Z.
Su, Li-Ming
author_facet Akhavein, Arash
Han, Julia
Carter, Christopher
Al-Quran, Samer Z.
Su, Li-Ming
author_sort Akhavein, Arash
collection PubMed
description Xp11 translocation renal cell carcinoma (TRCC) is a rare subtype of renal cell carcinoma characterized by chromosomal translocations involving the TFE3 gene located at the Xp11.2 locus. Initial cases were more common in children, but cases in older adults have begun to accrue and suggest a relatively more aggressive course. We report a case of Xp11 TRCC in a 63-year-old female patient with initial presentation mimicking upper urinary tract urothelial cell carcinoma, with biopsy proving TRCC. She underwent a radical nephrectomy and paracaval lymph node dissection and is followed up with the intent to initiate vascular endothelial growth factor–targeted therapy in case of recurrence.
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spelling pubmed-47330072016-03-07 Xp11 Translocation Renal Cell Carcinoma: Unusual Variant Masquerading as Upper Tract Urothelial Cell Carcinoma Akhavein, Arash Han, Julia Carter, Christopher Al-Quran, Samer Z. Su, Li-Ming Urol Case Rep Oncology Xp11 translocation renal cell carcinoma (TRCC) is a rare subtype of renal cell carcinoma characterized by chromosomal translocations involving the TFE3 gene located at the Xp11.2 locus. Initial cases were more common in children, but cases in older adults have begun to accrue and suggest a relatively more aggressive course. We report a case of Xp11 TRCC in a 63-year-old female patient with initial presentation mimicking upper urinary tract urothelial cell carcinoma, with biopsy proving TRCC. She underwent a radical nephrectomy and paracaval lymph node dissection and is followed up with the intent to initiate vascular endothelial growth factor–targeted therapy in case of recurrence. Elsevier 2014-03-31 /pmc/articles/PMC4733007/ /pubmed/26955551 http://dx.doi.org/10.1016/j.eucr.2014.02.003 Text en © 2014 The Authors http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Oncology
Akhavein, Arash
Han, Julia
Carter, Christopher
Al-Quran, Samer Z.
Su, Li-Ming
Xp11 Translocation Renal Cell Carcinoma: Unusual Variant Masquerading as Upper Tract Urothelial Cell Carcinoma
title Xp11 Translocation Renal Cell Carcinoma: Unusual Variant Masquerading as Upper Tract Urothelial Cell Carcinoma
title_full Xp11 Translocation Renal Cell Carcinoma: Unusual Variant Masquerading as Upper Tract Urothelial Cell Carcinoma
title_fullStr Xp11 Translocation Renal Cell Carcinoma: Unusual Variant Masquerading as Upper Tract Urothelial Cell Carcinoma
title_full_unstemmed Xp11 Translocation Renal Cell Carcinoma: Unusual Variant Masquerading as Upper Tract Urothelial Cell Carcinoma
title_short Xp11 Translocation Renal Cell Carcinoma: Unusual Variant Masquerading as Upper Tract Urothelial Cell Carcinoma
title_sort xp11 translocation renal cell carcinoma: unusual variant masquerading as upper tract urothelial cell carcinoma
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4733007/
https://www.ncbi.nlm.nih.gov/pubmed/26955551
http://dx.doi.org/10.1016/j.eucr.2014.02.003
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