Exercise-induced mitochondrial p53 repairs mtDNA mutations in mutator mice

BACKGROUND: Human genetic disorders and transgenic mouse models have shown that mitochondrial DNA (mtDNA) mutations and telomere dysfunction instigate the aging process. Epidemiologically, exercise is associated with greater life expectancy and reduced risk of chronic diseases. While the beneficial...

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Detalles Bibliográficos
Autores principales: Safdar, Adeel, Khrapko, Konstantin, Flynn, James M., Saleem, Ayesha, De Lisio, Michael, Johnston, Adam P. W., Kratysberg, Yevgenya, Samjoo, Imtiaz A., Kitaoka, Yu, Ogborn, Daniel I., Little, Jonathan P., Raha, Sandeep, Parise, Gianni, Akhtar, Mahmood, Hettinga, Bart P., Rowe, Glenn C., Arany, Zoltan, Prolla, Tomas A., Tarnopolsky, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4733510/
https://www.ncbi.nlm.nih.gov/pubmed/26834962
http://dx.doi.org/10.1186/s13395-016-0075-9

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