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Different Eukaryotic Initiation Factor 2Bε Mutations Lead to Various Degrees of Intolerance to the Stress of Endoplasmic Reticulum in Oligodendrocytes

BACKGROUND: Vanishing white matter disease (VWM), a human autosomal recessive inherited leukoencephalopathy, is due to mutations in eukaryotic initiation factor 2B (eIF2B). eIF2B is responsible for the initiation of protein synthesis by its guanine nucleotide exchange factor (GEF) activity. Mutation...

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Detalles Bibliográficos
Autores principales:	Chen, Na, Jiang, Yu-Wu, Hao, Hong-Jun, Ban, Ting-Ting, Gao, Kai, Zhang, Zhong-Bin, Wang, Jing-Min, Wu, Ye
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Medknow Publications & Media Pvt Ltd 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4733711/ https://www.ncbi.nlm.nih.gov/pubmed/26112719 http://dx.doi.org/10.4103/0366-6999.159353

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