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Mutations of Conserved Residues in the Major Homology Region Arrest Assembling HIV-1 Gag as a Membrane-Targeted Intermediate Containing Genomic RNA and Cellular Proteins

The major homology region (MHR) is a highly conserved motif that is found within the Gag protein of all orthoretroviruses and some retrotransposons. While it is widely accepted that the MHR is critical for assembly of HIV-1 and other retroviruses, how the MHR functions and why it is so highly conser...

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Detalles Bibliográficos
Autores principales:	Tanaka, Motoko, Robinson, Bridget A., Chutiraka, Kasana, Geary, Clair D., Reed, Jonathan C., Lingappa, Jaisri R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2016
Materias:	Structure and Assembly
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734008/ https://www.ncbi.nlm.nih.gov/pubmed/26656702 http://dx.doi.org/10.1128/JVI.02698-15

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