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A Non-inflammatory Role for Microglia in Autism Spectrum Disorders

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social interaction, difficulties with language, and repetitive/restricted behaviors. The etiology of ASD is still largely unclear, but immune dysfunction and abnormalities in synaptogenesis have repeatedly b...

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Detalles Bibliográficos
Autores principales: Edmonson, Catherine A., Ziats, Mark N., Rennert, Owen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734207/
https://www.ncbi.nlm.nih.gov/pubmed/26869989
http://dx.doi.org/10.3389/fneur.2016.00009
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author Edmonson, Catherine A.
Ziats, Mark N.
Rennert, Owen M.
author_facet Edmonson, Catherine A.
Ziats, Mark N.
Rennert, Owen M.
author_sort Edmonson, Catherine A.
collection PubMed
description Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social interaction, difficulties with language, and repetitive/restricted behaviors. The etiology of ASD is still largely unclear, but immune dysfunction and abnormalities in synaptogenesis have repeatedly been implicated as contributing to the disease phenotype. However, an understanding of how and if these two processes are related has not firmly been established. As non-inflammatory roles of microglia become increasingly recognized as critical to normal neurodevelopment, it is important to consider how dysfunction in these processes might explain the seemingly disparate findings of immune dysfunction and aberrant synaptogenesis seen in ASD. In this review, we highlight research demonstrating the importance of microglia to the development of normal neural networks, review recent studies demonstrating abnormal microglia in autism, and discuss how the relationship between these processes may contribute to the development of autism and other neurodevelopmental disorders at the cellular level.
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spelling pubmed-47342072016-02-11 A Non-inflammatory Role for Microglia in Autism Spectrum Disorders Edmonson, Catherine A. Ziats, Mark N. Rennert, Owen M. Front Neurol Neuroscience Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social interaction, difficulties with language, and repetitive/restricted behaviors. The etiology of ASD is still largely unclear, but immune dysfunction and abnormalities in synaptogenesis have repeatedly been implicated as contributing to the disease phenotype. However, an understanding of how and if these two processes are related has not firmly been established. As non-inflammatory roles of microglia become increasingly recognized as critical to normal neurodevelopment, it is important to consider how dysfunction in these processes might explain the seemingly disparate findings of immune dysfunction and aberrant synaptogenesis seen in ASD. In this review, we highlight research demonstrating the importance of microglia to the development of normal neural networks, review recent studies demonstrating abnormal microglia in autism, and discuss how the relationship between these processes may contribute to the development of autism and other neurodevelopmental disorders at the cellular level. Frontiers Media S.A. 2016-02-01 /pmc/articles/PMC4734207/ /pubmed/26869989 http://dx.doi.org/10.3389/fneur.2016.00009 Text en Copyright © 2016 Edmonson, Ziats and Rennert. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Edmonson, Catherine A.
Ziats, Mark N.
Rennert, Owen M.
A Non-inflammatory Role for Microglia in Autism Spectrum Disorders
title A Non-inflammatory Role for Microglia in Autism Spectrum Disorders
title_full A Non-inflammatory Role for Microglia in Autism Spectrum Disorders
title_fullStr A Non-inflammatory Role for Microglia in Autism Spectrum Disorders
title_full_unstemmed A Non-inflammatory Role for Microglia in Autism Spectrum Disorders
title_short A Non-inflammatory Role for Microglia in Autism Spectrum Disorders
title_sort non-inflammatory role for microglia in autism spectrum disorders
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734207/
https://www.ncbi.nlm.nih.gov/pubmed/26869989
http://dx.doi.org/10.3389/fneur.2016.00009
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