Counterion effects on nano-confined metal–drug–DNA complexes

We have explored morphology of DNA molecules bound with Cu complexes of piroxicam (a non-steroidal anti-inflammatory drug) molecules under one-dimensional confinement of thin films and have studied the effect of counterions present in a buffer. X-ray reflectivity at and away from the Cu K absorption...

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Autores principales: Biswas, Nupur, Chakraborty, Sreeja, Datta, Alokmay, Sarkar, Munna, Mukhopadhyay, Mrinmay K, Bera, Mrinal K, Seto, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2016
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734432/
https://www.ncbi.nlm.nih.gov/pubmed/26925353
http://dx.doi.org/10.3762/bjnano.7.7
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author Biswas, Nupur
Chakraborty, Sreeja
Datta, Alokmay
Sarkar, Munna
Mukhopadhyay, Mrinmay K
Bera, Mrinal K
Seto, Hideki
author_facet Biswas, Nupur
Chakraborty, Sreeja
Datta, Alokmay
Sarkar, Munna
Mukhopadhyay, Mrinmay K
Bera, Mrinal K
Seto, Hideki
author_sort Biswas, Nupur
collection PubMed
description We have explored morphology of DNA molecules bound with Cu complexes of piroxicam (a non-steroidal anti-inflammatory drug) molecules under one-dimensional confinement of thin films and have studied the effect of counterions present in a buffer. X-ray reflectivity at and away from the Cu K absorption edge and atomic force microscopy studies reveal that confinement segregates the drug molecules preferentially in a top layer of the DNA film, and counterions enhance this segregation.
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spelling pubmed-47344322016-02-26 Counterion effects on nano-confined metal–drug–DNA complexes Biswas, Nupur Chakraborty, Sreeja Datta, Alokmay Sarkar, Munna Mukhopadhyay, Mrinmay K Bera, Mrinal K Seto, Hideki Beilstein J Nanotechnol Full Research Paper We have explored morphology of DNA molecules bound with Cu complexes of piroxicam (a non-steroidal anti-inflammatory drug) molecules under one-dimensional confinement of thin films and have studied the effect of counterions present in a buffer. X-ray reflectivity at and away from the Cu K absorption edge and atomic force microscopy studies reveal that confinement segregates the drug molecules preferentially in a top layer of the DNA film, and counterions enhance this segregation. Beilstein-Institut 2016-01-19 /pmc/articles/PMC4734432/ /pubmed/26925353 http://dx.doi.org/10.3762/bjnano.7.7 Text en Copyright © 2016, Biswas et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjnano/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Nanotechnology terms and conditions: (https://www.beilstein-journals.org/bjnano/terms)
spellingShingle Full Research Paper
Biswas, Nupur
Chakraborty, Sreeja
Datta, Alokmay
Sarkar, Munna
Mukhopadhyay, Mrinmay K
Bera, Mrinal K
Seto, Hideki
Counterion effects on nano-confined metal–drug–DNA complexes
title Counterion effects on nano-confined metal–drug–DNA complexes
title_full Counterion effects on nano-confined metal–drug–DNA complexes
title_fullStr Counterion effects on nano-confined metal–drug–DNA complexes
title_full_unstemmed Counterion effects on nano-confined metal–drug–DNA complexes
title_short Counterion effects on nano-confined metal–drug–DNA complexes
title_sort counterion effects on nano-confined metal–drug–dna complexes
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734432/
https://www.ncbi.nlm.nih.gov/pubmed/26925353
http://dx.doi.org/10.3762/bjnano.7.7
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