Microevolution of Outbreak-Associated Middle East Respiratory Syndrome Coronavirus, South Korea, 2015

During the 2015 Middle East respiratory syndrome coronavirus outbreak in South Korea, we sequenced full viral genomes of strains isolated from 4 patients early and late during infection. Patients represented at least 4 generations of transmission. We found no evidence of changes in the evolutionary...

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Detalles Bibliográficos
Autores principales: Seong, Moon-Woo, Kim, So Yeon, Corman, Victor Max, Kim, Taek Soo, Cho, Sung Im, Kim, Man Jin, Lee, Seung Jun, Lee, Jee-Soo, Seo, Soo Hyun, Ahn, Ji Soo, Yu, Byeong Su, Park, Nare, Oh, Myoung-don, Park, Wan Beom, Lee, Ji Yeon, Kim, Gayeon, Joh, Joon Sung, Jeong, Ina, Kim, Eui Chong, Drosten, Christian, Park, Sung Sup
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2016
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734539/
https://www.ncbi.nlm.nih.gov/pubmed/26814649
http://dx.doi.org/10.3201/eid2202.151700
Descripción
Sumario:During the 2015 Middle East respiratory syndrome coronavirus outbreak in South Korea, we sequenced full viral genomes of strains isolated from 4 patients early and late during infection. Patients represented at least 4 generations of transmission. We found no evidence of changes in the evolutionary rate and no reason to suspect adaptive changes in viral proteins.

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