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Microevolution of Outbreak-Associated Middle East Respiratory Syndrome Coronavirus, South Korea, 2015

During the 2015 Middle East respiratory syndrome coronavirus outbreak in South Korea, we sequenced full viral genomes of strains isolated from 4 patients early and late during infection. Patients represented at least 4 generations of transmission. We found no evidence of changes in the evolutionary...

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Autores principales: Seong, Moon-Woo, Kim, So Yeon, Corman, Victor Max, Kim, Taek Soo, Cho, Sung Im, Kim, Man Jin, Lee, Seung Jun, Lee, Jee-Soo, Seo, Soo Hyun, Ahn, Ji Soo, Yu, Byeong Su, Park, Nare, Oh, Myoung-don, Park, Wan Beom, Lee, Ji Yeon, Kim, Gayeon, Joh, Joon Sung, Jeong, Ina, Kim, Eui Chong, Drosten, Christian, Park, Sung Sup
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734539/
https://www.ncbi.nlm.nih.gov/pubmed/26814649
http://dx.doi.org/10.3201/eid2202.151700
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author Seong, Moon-Woo
Kim, So Yeon
Corman, Victor Max
Kim, Taek Soo
Cho, Sung Im
Kim, Man Jin
Lee, Seung Jun
Lee, Jee-Soo
Seo, Soo Hyun
Ahn, Ji Soo
Yu, Byeong Su
Park, Nare
Oh, Myoung-don
Park, Wan Beom
Lee, Ji Yeon
Kim, Gayeon
Joh, Joon Sung
Jeong, Ina
Kim, Eui Chong
Drosten, Christian
Park, Sung Sup
author_facet Seong, Moon-Woo
Kim, So Yeon
Corman, Victor Max
Kim, Taek Soo
Cho, Sung Im
Kim, Man Jin
Lee, Seung Jun
Lee, Jee-Soo
Seo, Soo Hyun
Ahn, Ji Soo
Yu, Byeong Su
Park, Nare
Oh, Myoung-don
Park, Wan Beom
Lee, Ji Yeon
Kim, Gayeon
Joh, Joon Sung
Jeong, Ina
Kim, Eui Chong
Drosten, Christian
Park, Sung Sup
author_sort Seong, Moon-Woo
collection PubMed
description During the 2015 Middle East respiratory syndrome coronavirus outbreak in South Korea, we sequenced full viral genomes of strains isolated from 4 patients early and late during infection. Patients represented at least 4 generations of transmission. We found no evidence of changes in the evolutionary rate and no reason to suspect adaptive changes in viral proteins.
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spelling pubmed-47345392016-02-11 Microevolution of Outbreak-Associated Middle East Respiratory Syndrome Coronavirus, South Korea, 2015 Seong, Moon-Woo Kim, So Yeon Corman, Victor Max Kim, Taek Soo Cho, Sung Im Kim, Man Jin Lee, Seung Jun Lee, Jee-Soo Seo, Soo Hyun Ahn, Ji Soo Yu, Byeong Su Park, Nare Oh, Myoung-don Park, Wan Beom Lee, Ji Yeon Kim, Gayeon Joh, Joon Sung Jeong, Ina Kim, Eui Chong Drosten, Christian Park, Sung Sup Emerg Infect Dis Dispatch During the 2015 Middle East respiratory syndrome coronavirus outbreak in South Korea, we sequenced full viral genomes of strains isolated from 4 patients early and late during infection. Patients represented at least 4 generations of transmission. We found no evidence of changes in the evolutionary rate and no reason to suspect adaptive changes in viral proteins. Centers for Disease Control and Prevention 2016-02 /pmc/articles/PMC4734539/ /pubmed/26814649 http://dx.doi.org/10.3201/eid2202.151700 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Dispatch
Seong, Moon-Woo
Kim, So Yeon
Corman, Victor Max
Kim, Taek Soo
Cho, Sung Im
Kim, Man Jin
Lee, Seung Jun
Lee, Jee-Soo
Seo, Soo Hyun
Ahn, Ji Soo
Yu, Byeong Su
Park, Nare
Oh, Myoung-don
Park, Wan Beom
Lee, Ji Yeon
Kim, Gayeon
Joh, Joon Sung
Jeong, Ina
Kim, Eui Chong
Drosten, Christian
Park, Sung Sup
Microevolution of Outbreak-Associated Middle East Respiratory Syndrome Coronavirus, South Korea, 2015
title Microevolution of Outbreak-Associated Middle East Respiratory Syndrome Coronavirus, South Korea, 2015
title_full Microevolution of Outbreak-Associated Middle East Respiratory Syndrome Coronavirus, South Korea, 2015
title_fullStr Microevolution of Outbreak-Associated Middle East Respiratory Syndrome Coronavirus, South Korea, 2015
title_full_unstemmed Microevolution of Outbreak-Associated Middle East Respiratory Syndrome Coronavirus, South Korea, 2015
title_short Microevolution of Outbreak-Associated Middle East Respiratory Syndrome Coronavirus, South Korea, 2015
title_sort microevolution of outbreak-associated middle east respiratory syndrome coronavirus, south korea, 2015
topic Dispatch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734539/
https://www.ncbi.nlm.nih.gov/pubmed/26814649
http://dx.doi.org/10.3201/eid2202.151700
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