Cargando…

Macrolides sensitize EGFR-TKI-induced non-apoptotic cell death via blocking autophagy flux in pancreatic cancer cell lines

Pancreatic cancer is one of the most difficult types of cancer to treat because of its high mortality rate due to chemotherapy resistance. We previously reported that combined treatment with gefitinib (GEF) and clarithromycin (CAM) results in enhanced cytotoxicity of GEF along with endoplasmic retic...

Descripción completa

Detalles Bibliográficos
Autores principales:	MUKAI, SHUNTARO, MORIYA, SHOTA, HIRAMOTO, MASAKI, KAZAMA, HIROMI, KOKUBA, HIROKO, CHE, XIAO-FANG, YOKOYAMA, TOMOHISA, SAKAMOTO, SATOSHI, SUGAWARA, AKIHIRO, SUNAZUKA, TOSHIAKI, ŌMURA, SATOSHI, HANDA, HIROSHI, ITOI, TAKAO, MIYAZAWA, KEISUKE
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2015
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734605/ https://www.ncbi.nlm.nih.gov/pubmed/26718641 http://dx.doi.org/10.3892/ijo.2015.3237

Ejemplares similares

Macrolide antibiotics enhance the antitumor effect of lansoprazole resulting in lysosomal membrane permeabilization-associated cell death
por: Takeda, Atsuo, et al.
Publicado: (2020)

Azithromycin enhances the cytotoxicity of DNA‐damaging drugs via lysosomal membrane permeabilization in lung cancer cells
por: Toriyama, Kazutoshi, et al.
Publicado: (2021)

Targeted disruption of GAK stagnates autophagic flux by disturbing lysosomal dynamics
por: Miyazaki, Masaya, et al.
Publicado: (2021)

Macrolide Antibiotics Exhibit Cytotoxic Effect under Amino Acid-Depleted Culture Condition by Blocking Autophagy Flux in Head and Neck Squamous Cell Carcinoma Cell Lines
por: Hirasawa, Kazuhiro, et al.
Publicado: (2016)

Abemaciclib induces atypical cell death in cancer cells characterized by formation of cytoplasmic vacuoles derived from lysosomes
por: Hino, Hirotsugu, et al.
Publicado: (2020)

Clarithromycin overcomes stromal cell-mediated drug resistance against proteasome inhibitors in myeloma cells via autophagy flux blockage leading to high NOXA expression
por: Moriya, Shota, et al.
Publicado: (2023)

Targeting bortezomib-induced aggresome formation using vinorelbine enhances the cytotoxic effect along with ER stress loading in breast cancer cell lines
por: Miyahara, Kana, et al.
Publicado: (2016)

Amino acid starvation culture condition sensitizes EGFR-expressing cancer cell lines to gefitinib-mediated cytotoxicity by inducing atypical necroptosis
por: Saito, Yu, et al.
Publicado: (2018)

Induction of synergistic non-apoptotic cell death by simultaneously targeting proteasomes with bortezomib and histone deacetylase 6 with ricolinostat in head and neck tumor cells
por: Hattori, Kazuhiro, et al.
Publicado: (2021)

Macrolide antibiotics block autophagy flux and sensitize to bortezomib via endoplasmic reticulum stress-mediated CHOP induction in myeloma cells
por: MORIYA, SHOTA, et al.
Publicado: (2013)

The non-antibiotic macrolide EM900 inhibits rhinovirus infection and cytokine production in human airway epithelial cells
por: Lusamba Kalonji, Nadine, et al.
Publicado: (2015)

Visualization of ceramide channels in lysosomes following endogenous palmitoyl-ceramide accumulation as an initial step in the induction of necrosis
por: Yamane, Mototeru, et al.
Publicado: (2017)

Targeting the integrated networks of aggresome formation, proteasome, and autophagy potentiates ER stress-mediated cell death in multiple myeloma cells
por: MORIYA, SHOTA, et al.
Publicado: (2014)

The non-antibiotic macrolide EM900 attenuates HDM and poly(I:C)-induced airway inflammation with inhibition of macrophages in a mouse model
por: Sadamatsu, Hironori, et al.
Publicado: (2019)

Comparison of autophagy inducibility in various tyrosine kinase inhibitors and their enhanced cytotoxicity via inhibition of autophagy in cancer cells in combined treatment with azithromycin
por: Tanaka, Hideki, et al.
Publicado: (2020)

Recent development of two chitinase inhibitors, Argifin and Argadin, produced by soil microorganisms
por: Hirose, Tomoyasu, et al.
Publicado: (2010)

Azithromycin, a potent autophagy inhibitor for cancer therapy, perturbs cytoskeletal protein dynamics
por: Takano, Naoharu, et al.
Publicado: (2023)

How should we use endoscopic ultrasonography-guided biliary drainage techniques separately?
por: Mukai, Shuntaro, et al.
Publicado: (2016)

EUS-guided antegrade procedures
por: Mukai, Shuntaro, et al.
Publicado: (2019)

Synthesis of pyripyropene derivatives and their pest-control efficacy
por: Goto, Kimihiko, et al.
Publicado: (2019)

Ricolinostat enhances adavosertib-induced mitotic catastrophe in TP53-mutated head and neck squamous cell carcinoma cells
por: Miyake, Keitaro, et al.
Publicado: (2022)

Synthesis and stereochemical determination of an antiparasitic pseudo-aminal type monoterpene indole alkaloid
por: Noguchi, Yoshihiko, et al.
Publicado: (2016)

Afidopyropen, a novel insecticide originating from microbial secondary extracts
por: Horikoshi, Ryo, et al.
Publicado: (2022)

The Role of Artificial Intelligence in Endoscopic Ultrasound for Pancreatic Disorders
por: Tonozuka, Ryosuke, et al.
Publicado: (2020)

BRCA1 degradation in response to mitochondrial damage in breast cancer cells
por: Miyahara, Kana, et al.
Publicado: (2021)

An animal experimental study to assess the core tissue acquisition ability of endoscopic ultrasound-guided histology needles
por: Mukai, Shuntaro, et al.
Publicado: (2018)

Lysosome-targeted drug combination induces multiple organelle dysfunctions and non-canonical death in pancreatic cancer cells
por: Suzuki, Sumire, et al.
Publicado: (2022)

Antimalarial troponoids, puberulic acid and viticolins; divergent synthesis and structure-activity relationship studies
por: Sennari, Goh, et al.
Publicado: (2017)

Thioporidiols A and B: Two New Sulfur Compounds Discovered by Molybdenum-Catalyzed Oxidation Screening from Trichoderma polypori FKI-7382
por: Matsuo, Hirotaka, et al.
Publicado: (2020)

Application of plasma alternative to serum for measuring leucine-rich α2-glycoprotein as a biomarker of inflammatory bowel disease
por: Ichimiya, Tadashi, et al.
Publicado: (2023)

EUS-guided rendezvous technique for refractory benign biliary stricture caused by postoperative bile-duct injury
por: Matsunami, Yukitoshi, et al.
Publicado: (2017)

Recanalization after biliojejunostomy by use of a new digital per-oral cholangioscope through the hepaticogastrostomy route
por: Tonozuka, Ryosuke, et al.
Publicado: (2016)

Endoscopic removal of an inward migrated pancreatic duct stent with use of a small biopsy forceps through a dilator
por: Yamamoto, Kenjiro, et al.
Publicado: (2016)

Endoscopic Ultrasonography-Guided Gastroenterostomy Techniques for Treatment of Malignant Gastric Outlet Obstruction
por: Tonozuka, Ryosuke, et al.
Publicado: (2020)

TKI safety
por: Hjorth-Hansen, Henrik
Publicado: (2019)

Macrolides Decrease the Proinflammatory Activity of Macrolide-Resistant Streptococcus pneumoniae
por: Domon, Hisanori, et al.
Publicado: (2023)

Mallory‐Weise syndrome in a patient treated with EGFR‐TKI
por: Okauchi, Shinichiro, et al.
Publicado: (2017)

Macrolide antibiotics exert antileukemic effects by modulating the autophagic flux through inhibition of hERG1 potassium channels
por: Pillozzi, S, et al.
Publicado: (2016)

Influence of Repeated Senna Laxative Use on Skin Barrier Function in Mice
por: Yokoyama, Satoshi, et al.
Publicado: (2017)

Macrolide versus Non-Macrolide in Combination with Steroids for the Treatment of Lobar or Segmental Mycoplasma pneumoniae Pneumonia Unresponsive to Initial Macrolide Monotherapy
por: Bae, Eunha, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_kab027tt5p52iodfgq4cg51ltr