Epigenetic regulation in AKI: new light in a dark area

Epigenetic mechanisms have been implicated in the pathogenesis of renal diseases, including acute kidney injury. Mar et. al. now unravel the acetylation and methylation at histones that are associated with the transcription of key genes in AKI. Notably, histone modifications display a remarkable het...

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Detalles Bibliográficos
Autores principales: Tang, Chengyuan, Dong, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734625/
https://www.ncbi.nlm.nih.gov/pubmed/26422622
http://dx.doi.org/10.1038/ki.2015.229
Descripción
Sumario:Epigenetic mechanisms have been implicated in the pathogenesis of renal diseases, including acute kidney injury. Mar et. al. now unravel the acetylation and methylation at histones that are associated with the transcription of key genes in AKI. Notably, histone modifications display a remarkable heterogeneity in ischemic and endotoxic AKI. Targeting epigenetic programs may offer novel strategies to protect kidneys from AKI and enhance kidney repair and recovery.

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