Epigenetic regulation in AKI: new light in a dark area

Epigenetic mechanisms have been implicated in the pathogenesis of renal diseases, including acute kidney injury. Mar et. al. now unravel the acetylation and methylation at histones that are associated with the transcription of key genes in AKI. Notably, histone modifications display a remarkable het...

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Detalles Bibliográficos
Autores principales: Tang, Chengyuan, Dong, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734625/
https://www.ncbi.nlm.nih.gov/pubmed/26422622
http://dx.doi.org/10.1038/ki.2015.229
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author Tang, Chengyuan
Dong, Zheng
author_facet Tang, Chengyuan
Dong, Zheng
author_sort Tang, Chengyuan
collection PubMed
description Epigenetic mechanisms have been implicated in the pathogenesis of renal diseases, including acute kidney injury. Mar et. al. now unravel the acetylation and methylation at histones that are associated with the transcription of key genes in AKI. Notably, histone modifications display a remarkable heterogeneity in ischemic and endotoxic AKI. Targeting epigenetic programs may offer novel strategies to protect kidneys from AKI and enhance kidney repair and recovery.
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spelling pubmed-47346252016-04-01 Epigenetic regulation in AKI: new light in a dark area Tang, Chengyuan Dong, Zheng Kidney Int Article Epigenetic mechanisms have been implicated in the pathogenesis of renal diseases, including acute kidney injury. Mar et. al. now unravel the acetylation and methylation at histones that are associated with the transcription of key genes in AKI. Notably, histone modifications display a remarkable heterogeneity in ischemic and endotoxic AKI. Targeting epigenetic programs may offer novel strategies to protect kidneys from AKI and enhance kidney repair and recovery. 2015-10 /pmc/articles/PMC4734625/ /pubmed/26422622 http://dx.doi.org/10.1038/ki.2015.229 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Tang, Chengyuan
Dong, Zheng
Epigenetic regulation in AKI: new light in a dark area
title Epigenetic regulation in AKI: new light in a dark area
title_full Epigenetic regulation in AKI: new light in a dark area
title_fullStr Epigenetic regulation in AKI: new light in a dark area
title_full_unstemmed Epigenetic regulation in AKI: new light in a dark area
title_short Epigenetic regulation in AKI: new light in a dark area
title_sort epigenetic regulation in aki: new light in a dark area
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734625/
https://www.ncbi.nlm.nih.gov/pubmed/26422622
http://dx.doi.org/10.1038/ki.2015.229
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