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Leptin and Pro-Inflammatory Stimuli Synergistically Upregulate MMP-1 and MMP-3 Secretion in Human Gingival Fibroblasts

INTRODUCTION: Gingival fibroblast-mediated extracellular matrix remodelling is implicated in the pathogenesis of periodontitis, yet the stimuli that regulate this response are not fully understood. The immunoregulatory adipokine leptin is detectable in the gingiva, human gingival fibroblasts express...

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Detalles Bibliográficos
Autores principales:	Williams, Rachel C., Skelton, Andrew J., Todryk, Stephen M., Rowan, Andrew D., Preshaw, Philip M., Taylor, John J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734666/ https://www.ncbi.nlm.nih.gov/pubmed/26829555 http://dx.doi.org/10.1371/journal.pone.0148024

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