Graded Proteasome Dysfunction in Caenorhabditis elegans Activates an Adaptive Response Involving the Conserved SKN-1 and ELT-2 Transcription Factors and the Autophagy-Lysosome Pathway

The maintenance of cellular proteins in a biologically active and structurally stable state is a vital endeavor involving multiple cellular pathways. One such pathway is the ubiquitin-proteasome system that represents a major route for protein degradation, and reductions in this pathway usually have...

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Detalles Bibliográficos
Autores principales: Keith, Scott A., Maddux, Sarah K., Zhong, Yayu, Chinchankar, Meghna N., Ferguson, Annabel A., Ghazi, Arjumand, Fisher, Alfred L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734690/
https://www.ncbi.nlm.nih.gov/pubmed/26828939
http://dx.doi.org/10.1371/journal.pgen.1005823

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