Cargando…

Analysis of Genes Involved in Body Weight Regulation by Targeted Re-Sequencing

INTRODUCTION: Genes involved in body weight regulation that were previously investigated in genome-wide association studies (GWAS) and in animal models were target-enriched followed by massive parallel next generation sequencing. METHODS: We enriched and re-sequenced continuous genomic regions compr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Volckmar, Anna-Lena, Han, Chung Ting, Pütter, Carolin, Haas, Stefan, Vogel, Carla I. G., Knoll, Nadja, Struve, Christoph, Göbel, Maria, Haas, Katharina, Herrfurth, Nikolas, Jarick, Ivonne, Grallert, Harald, Schürmann, Annette, Al-Hasani, Hadi, Hebebrand, Johannes, Sauer, Sascha, Hinney, Anke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734691/ https://www.ncbi.nlm.nih.gov/pubmed/26828654 http://dx.doi.org/10.1371/journal.pone.0147904

Ejemplares similares

Fine Mapping of a GWAS-Derived Obesity Candidate Region on Chromosome 16p11.2
por: Volckmar, Anna-Lena, et al.
Publicado: (2015)

Gene Set of Nuclear-Encoded Mitochondrial Regulators Is Enriched for Common Inherited Variation in Obesity
por: Knoll, Nadja, et al.
Publicado: (2013)

Investigation of a Genome Wide Association Signal for Obesity: Synthetic Association and Haplotype Analyses at the Melanocortin 4 Receptor Gene Locus
por: Scherag, André, et al.
Publicado: (2010)

Mutation screen in the GWAS derived obesity gene SH2B1 including functional analyses of detected variants
por: Volckmar, Anna-Lena, et al.
Publicado: (2012)

Mitochondrial DNA Variants in Obesity
por: Knoll, Nadja, et al.
Publicado: (2014)

Novel common copy number variation for early onset extreme obesity on chromosome 11q11 identified by a genome-wide analysis
por: Jarick, Ivonne, et al.
Publicado: (2011)

Relevance of polymorphisms in MC4R and BDNF in short normal stature
por: Herrfurth, Nikolas, et al.
Publicado: (2018)

From monogenic to polygenic obesity: recent advances
por: Hinney, Anke, et al.
Publicado: (2010)

Val103Ile polymorphism of the melanocortin-4 receptor gene (MC4R) in cancer cachexia
por: Knoll, Susanne, et al.
Publicado: (2008)

Eating disorders: the current status of molecular genetic research
por: Scherag, Susann, et al.
Publicado: (2009)

Non-replication of an association of CTNNBL1 polymorphisms and obesity in a population of Central European ancestry
por: Vogel, Carla IG, et al.
Publicado: (2009)

Association of common variants identified by recent genome-wide association studies with obesity in Chinese children: a case-control study
por: Wang, Hai-Jun, et al.
Publicado: (2016)

Large effects on body mass index and insulin resistance of fat mass and obesity associated gene (FTO) variants in patients with polycystic ovary syndrome (PCOS)
por: Tan, Susanne, et al.
Publicado: (2010)

Evidence for correlations between BMI-associated SNPs and circRNAs
por: Rajcsanyi, Luisa Sophie, et al.
Publicado: (2022)

A Novel SP1/SP3 Dependent Intronic Enhancer Governing Transcription of the UCP3 Gene in Brown Adipocytes
por: Hoffmann, Christoph, et al.
Publicado: (2013)

Genome Wide Association (GWA) Study for Early Onset Extreme Obesity Supports the Role of Fat Mass and Obesity Associated Gene (FTO) Variants
por: Hinney, Anke, et al.
Publicado: (2007)

Gastric inhibitory polypeptide receptor: association analyses for obesity of several polymorphisms in large study groups
por: Vogel, Carla IG, et al.
Publicado: (2009)

Increased constraints on MC4R during primate and human evolution
por: Hughes, David A., et al.
Publicado: (2008)

Mutation screen and association studies for the fatty acid amide hydrolase (FAAH) gene and early onset and adult obesity
por: Müller, Timo D, et al.
Publicado: (2010)

Successful Treatment with Atomoxetine of an Adolescent Boy with Attention Deficit/Hyperactivity Disorder, Extreme Obesity, and Reduced Melanocortin 4 Receptor Function
por: Pott, Wilfried, et al.
Publicado: (2013)

Prevalence estimates of putatively pathogenic leptin variants in the gnomAD database
por: Rajcsanyi, Luisa Sophie, et al.
Publicado: (2022)

The Role of Genetic Variation of BMI, Body Composition, and Fat Distribution for Mental Traits and Disorders: A Look-Up and Mendelian Randomization Study
por: Peters, Triinu, et al.
Publicado: (2020)

Analysis of sequence variations in the suppressor of cytokine signaling (SOCS)-3 gene in extremely obese children and adolescents
por: Hölter, Katja, et al.
Publicado: (2007)

Indications for Potential Parent-of-Origin Effects within the FTO Gene
por: Liu, Xuanshi, et al.
Publicado: (2015)

Evaluation of the MC3R gene pertaining to body weight and height regulation and puberty development
por: Zheng, Yiran, et al.
Publicado: (2023)

Positional Cloning of Zinc Finger Domain Transcription Factor Zfp69, a Candidate Gene for Obesity-Associated Diabetes Contributed by Mouse Locus Nidd/SJL
por: Scherneck, Stephan, et al.
Publicado: (2009)

Genome-wide analysis of rare copy number variations reveals PARK2 as a candidate gene for attention-deficit/hyperactivity disorder
por: Jarick, I, et al.
Publicado: (2014)

Two New Loci for Body-Weight Regulation Identified in a Joint Analysis of Genome-Wide Association Studies for Early-Onset Extreme Obesity in French and German Study Groups
por: Scherag, André, et al.
Publicado: (2010)

Melanocortin-4 Receptor and Lipocalin 2 Gene Variants in Spanish Children with Abdominal Obesity: Effects on BMI-SDS after a Lifestyle Intervention
por: Morell-Azanza, Lydia, et al.
Publicado: (2019)

A mendelian randomization study on causal effects of 25(OH)vitamin D levels on attention deficit/hyperactivity disorder
por: Libuda, Lars, et al.
Publicado: (2020)

Causal Effect of Age at Menarche on the Risk for Depression: Results From a Two-Sample Multivariable Mendelian Randomization Study
por: Hirtz, Raphael, et al.
Publicado: (2022)

'Fat mass and obesity associated' gene (FTO): No significant association of variant rs9939609 with weight loss in a lifestyle intervention and lipid metabolism markers in German obese children and adolescents
por: Müller, Timo D, et al.
Publicado: (2008)

Effect of an vitamin D deficiency on depressive symptoms in child and adolescent psychiatric patients – a randomized controlled trial: study protocol
por: Föcker, Manuel, et al.
Publicado: (2018)

Identification of Novel Genes Involved in Hyperglycemia in Mice
por: Jonas, Wenke, et al.
Publicado: (2022)

Mutation screen and association studies in the Diacylglycerol O-acyltransferase homolog 2 gene (DGAT2), a positional candidate gene for early onset obesity on chromosome 11q13
por: Friedel, Susann, et al.
Publicado: (2007)

Meta-analysis on the effect of the N363S polymorphism of the glucocorticoid receptor gene (GRL) on human obesity
por: Marti, Amelia, et al.
Publicado: (2006)

Suggestive Evidence for Causal Effect of Leptin Levels on Risk for Anorexia Nervosa: Results of a Mendelian Randomization Study
por: Peters, Triinu, et al.
Publicado: (2021)

Size Matters: The CAG Repeat Length of the Androgen Receptor Gene, Testosterone, and Male Adolescent Depression Severity
por: Hirtz, Raphael, et al.
Publicado: (2021)

The role of genetic variation of human metabolism for BMI, mental traits and mental disorders
por: Hebebrand, Johannes, et al.
Publicado: (2018)

Identification of novel transcriptional regulators involved in macrophage differentiation and activation in U937 cells
por: Baek, Young-Sook, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_3k3hggba8stgmc3mskke803hp4