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Targeting netrin‐1/DCC interaction in diffuse large B‐cell and mantle cell lymphomas

DCC (Deleted in Colorectal Carcinoma) has been demonstrated to constrain tumor progression by inducing apoptosis unless engaged by its ligand netrin‐1. This has been shown in breast and colorectal cancers; however, this tumor suppressive function in other cancers is not established. Using a transgen...

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Autores principales: Broutier, Laura, Creveaux, Marion, Vial, Jonathan, Tortereau, Antonin, Delcros, Jean‐Guy, Chazot, Guillaume, McCarron, Mark J, Léon, Sophie, Pangault, Céline, Gadot, Nicolas, Colombe, Amélie, Boulland, Marie‐Laure, Blachier, Jonathan, Marie, Julien C, Traverse‐Glehen, Alexandra, Donzé, Olivier, Chassagne‐Clément, Catherine, Salles, Gilles, Tarte, Karin, Mehlen, Patrick, Castets, Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734837/
https://www.ncbi.nlm.nih.gov/pubmed/26882243
http://dx.doi.org/10.15252/emmm.201505480
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author Broutier, Laura
Creveaux, Marion
Vial, Jonathan
Tortereau, Antonin
Delcros, Jean‐Guy
Chazot, Guillaume
McCarron, Mark J
Léon, Sophie
Pangault, Céline
Gadot, Nicolas
Colombe, Amélie
Boulland, Marie‐Laure
Blachier, Jonathan
Marie, Julien C
Traverse‐Glehen, Alexandra
Donzé, Olivier
Chassagne‐Clément, Catherine
Salles, Gilles
Tarte, Karin
Mehlen, Patrick
Castets, Marie
author_facet Broutier, Laura
Creveaux, Marion
Vial, Jonathan
Tortereau, Antonin
Delcros, Jean‐Guy
Chazot, Guillaume
McCarron, Mark J
Léon, Sophie
Pangault, Céline
Gadot, Nicolas
Colombe, Amélie
Boulland, Marie‐Laure
Blachier, Jonathan
Marie, Julien C
Traverse‐Glehen, Alexandra
Donzé, Olivier
Chassagne‐Clément, Catherine
Salles, Gilles
Tarte, Karin
Mehlen, Patrick
Castets, Marie
author_sort Broutier, Laura
collection PubMed
description DCC (Deleted in Colorectal Carcinoma) has been demonstrated to constrain tumor progression by inducing apoptosis unless engaged by its ligand netrin‐1. This has been shown in breast and colorectal cancers; however, this tumor suppressive function in other cancers is not established. Using a transgenic mouse model, we report here that inhibition of DCC‐induced apoptosis is associated with lymphomagenesis. In human diffuse large B‐cell lymphoma (DLBCL), an imbalance of the netrin‐1/DCC ratio suggests a loss of DCC‐induced apoptosis, either via a decrease in DCC expression in germinal center subtype or by up‐regulation of netrin‐1 in activated B‐cell (ABC) one. Such imbalance is also observed in mantle cell lymphoma (MCL). Using a netrin‐1 interfering antibody, we demonstrate both in vitro and in vivo that netrin‐1 acts as a survival factor for ABC‐DLBCL and MCL tumor cells. Together, these data suggest that interference with the netrin‐1/DCC interaction could represent a promising therapeutic strategy in netrin‐1‐positive DLBCL and MCL.
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spelling pubmed-47348372016-02-09 Targeting netrin‐1/DCC interaction in diffuse large B‐cell and mantle cell lymphomas Broutier, Laura Creveaux, Marion Vial, Jonathan Tortereau, Antonin Delcros, Jean‐Guy Chazot, Guillaume McCarron, Mark J Léon, Sophie Pangault, Céline Gadot, Nicolas Colombe, Amélie Boulland, Marie‐Laure Blachier, Jonathan Marie, Julien C Traverse‐Glehen, Alexandra Donzé, Olivier Chassagne‐Clément, Catherine Salles, Gilles Tarte, Karin Mehlen, Patrick Castets, Marie EMBO Mol Med Reports DCC (Deleted in Colorectal Carcinoma) has been demonstrated to constrain tumor progression by inducing apoptosis unless engaged by its ligand netrin‐1. This has been shown in breast and colorectal cancers; however, this tumor suppressive function in other cancers is not established. Using a transgenic mouse model, we report here that inhibition of DCC‐induced apoptosis is associated with lymphomagenesis. In human diffuse large B‐cell lymphoma (DLBCL), an imbalance of the netrin‐1/DCC ratio suggests a loss of DCC‐induced apoptosis, either via a decrease in DCC expression in germinal center subtype or by up‐regulation of netrin‐1 in activated B‐cell (ABC) one. Such imbalance is also observed in mantle cell lymphoma (MCL). Using a netrin‐1 interfering antibody, we demonstrate both in vitro and in vivo that netrin‐1 acts as a survival factor for ABC‐DLBCL and MCL tumor cells. Together, these data suggest that interference with the netrin‐1/DCC interaction could represent a promising therapeutic strategy in netrin‐1‐positive DLBCL and MCL. John Wiley and Sons Inc. 2016-02-01 2016-02 /pmc/articles/PMC4734837/ /pubmed/26882243 http://dx.doi.org/10.15252/emmm.201505480 Text en © 2016 The Authors. Published under the terms of the CC BY 4.0 license This is an open access article under the terms of the Creative Commons Attribution 4.0 (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reports
Broutier, Laura
Creveaux, Marion
Vial, Jonathan
Tortereau, Antonin
Delcros, Jean‐Guy
Chazot, Guillaume
McCarron, Mark J
Léon, Sophie
Pangault, Céline
Gadot, Nicolas
Colombe, Amélie
Boulland, Marie‐Laure
Blachier, Jonathan
Marie, Julien C
Traverse‐Glehen, Alexandra
Donzé, Olivier
Chassagne‐Clément, Catherine
Salles, Gilles
Tarte, Karin
Mehlen, Patrick
Castets, Marie
Targeting netrin‐1/DCC interaction in diffuse large B‐cell and mantle cell lymphomas
title Targeting netrin‐1/DCC interaction in diffuse large B‐cell and mantle cell lymphomas
title_full Targeting netrin‐1/DCC interaction in diffuse large B‐cell and mantle cell lymphomas
title_fullStr Targeting netrin‐1/DCC interaction in diffuse large B‐cell and mantle cell lymphomas
title_full_unstemmed Targeting netrin‐1/DCC interaction in diffuse large B‐cell and mantle cell lymphomas
title_short Targeting netrin‐1/DCC interaction in diffuse large B‐cell and mantle cell lymphomas
title_sort targeting netrin‐1/dcc interaction in diffuse large b‐cell and mantle cell lymphomas
topic Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734837/
https://www.ncbi.nlm.nih.gov/pubmed/26882243
http://dx.doi.org/10.15252/emmm.201505480
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