Cargando…
Centrosome amplification induces high grade features and is prognostic of worse outcomes in breast cancer
BACKGROUND: Centrosome amplification (CA) has been reported in nearly all types of human cancer and is associated with deleterious clinical factors such as higher grade and stage. However, previous reports have not shown how CA affects cellular differentiation and clinical outcomes in breast cancer....
Autores principales: | Denu, Ryan A., Zasadil, Lauren M., Kanugh, Craig, Laffin, Jennifer, Weaver, Beth A., Burkard, Mark E. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734858/ https://www.ncbi.nlm.nih.gov/pubmed/26832928 http://dx.doi.org/10.1186/s12885-016-2083-x |
Ejemplares similares
-
Analysis of the “centrosome-ome” identifies MCPH1 deletion as a cause of centrosome amplification in human cancer
por: Denu, Ryan A., et al.
Publicado: (2020) -
Centrosome amplification is a frequent event in circulating tumor cells from subjects with metastatic breast cancer
por: Singh, Ashok, et al.
Publicado: (2020) -
High nuclear TPX2 expression correlates with TP53 mutation and poor clinical behavior in a large breast cancer cohort, but is not an independent predictor of chromosomal instability
por: Matson, Daniel R., et al.
Publicado: (2021) -
PLK4 is upregulated in prostate cancer and its inhibition reduces centrosome amplification and causes senescence
por: Singh, Chandra K., et al.
Publicado: (2022) -
Cortical dynein drives centrosome clustering in cells with centrosome amplification
por: Mercadante, Dayna L., et al.
Publicado: (2023)