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N30 Somatosensory Evoked Potential Is Negatively Correlated with Motor Function in Parkinson’s Disease

OBJECTIVE: The aim of this study was to investigate frontal N30 status in Parkinson’s disease (PD) and to examine the correlation between the amplitude of frontal N30 and the severity of motor deficits. METHODS: The frontal N30 was compared between 17 PD patients and 18 healthy volunteers. Correlati...

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Autores principales: Kang, Suk Yun, Ma, Hyeo-Il
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Movement Disorders Society 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734986/
https://www.ncbi.nlm.nih.gov/pubmed/26828214
http://dx.doi.org/10.14802/jmd.15038
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author Kang, Suk Yun
Ma, Hyeo-Il
author_facet Kang, Suk Yun
Ma, Hyeo-Il
author_sort Kang, Suk Yun
collection PubMed
description OBJECTIVE: The aim of this study was to investigate frontal N30 status in Parkinson’s disease (PD) and to examine the correlation between the amplitude of frontal N30 and the severity of motor deficits. METHODS: The frontal N30 was compared between 17 PD patients and 18 healthy volunteers. Correlations between the amplitude of frontal N30 and the Unified Parkinson’s Disease Rating Scale (UPDRS) motor score of the more severely affected side was examined. RESULTS: The mean latency of the N30 was not significantly different between patients and healthy volunteers (p = 0.981), but the mean amplitude was lower in PD patients (p < 0.025). There was a significant negative correlation between the amplitude of N30 and the UPDRS motor score (r = -0.715, p = 0.013). CONCLUSIONS: The frontal N30 status indicates the motor severity of PD. It can be a useful biomarker reflecting dopaminergic deficits and an objective measurement for monitoring the clinical severity of PD.
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spelling pubmed-47349862016-02-08 N30 Somatosensory Evoked Potential Is Negatively Correlated with Motor Function in Parkinson’s Disease Kang, Suk Yun Ma, Hyeo-Il J Mov Disord Original Article OBJECTIVE: The aim of this study was to investigate frontal N30 status in Parkinson’s disease (PD) and to examine the correlation between the amplitude of frontal N30 and the severity of motor deficits. METHODS: The frontal N30 was compared between 17 PD patients and 18 healthy volunteers. Correlations between the amplitude of frontal N30 and the Unified Parkinson’s Disease Rating Scale (UPDRS) motor score of the more severely affected side was examined. RESULTS: The mean latency of the N30 was not significantly different between patients and healthy volunteers (p = 0.981), but the mean amplitude was lower in PD patients (p < 0.025). There was a significant negative correlation between the amplitude of N30 and the UPDRS motor score (r = -0.715, p = 0.013). CONCLUSIONS: The frontal N30 status indicates the motor severity of PD. It can be a useful biomarker reflecting dopaminergic deficits and an objective measurement for monitoring the clinical severity of PD. The Korean Movement Disorders Society 2016-01 2016-01-25 /pmc/articles/PMC4734986/ /pubmed/26828214 http://dx.doi.org/10.14802/jmd.15038 Text en Copyright © 2016 The Korean Movement Disorder Society This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kang, Suk Yun
Ma, Hyeo-Il
N30 Somatosensory Evoked Potential Is Negatively Correlated with Motor Function in Parkinson’s Disease
title N30 Somatosensory Evoked Potential Is Negatively Correlated with Motor Function in Parkinson’s Disease
title_full N30 Somatosensory Evoked Potential Is Negatively Correlated with Motor Function in Parkinson’s Disease
title_fullStr N30 Somatosensory Evoked Potential Is Negatively Correlated with Motor Function in Parkinson’s Disease
title_full_unstemmed N30 Somatosensory Evoked Potential Is Negatively Correlated with Motor Function in Parkinson’s Disease
title_short N30 Somatosensory Evoked Potential Is Negatively Correlated with Motor Function in Parkinson’s Disease
title_sort n30 somatosensory evoked potential is negatively correlated with motor function in parkinson’s disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734986/
https://www.ncbi.nlm.nih.gov/pubmed/26828214
http://dx.doi.org/10.14802/jmd.15038
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